Abstract

The purpose of Core A, the administrative/data coordination core is three fold. The first function is to provide the administrative support necessary for a project of this size involving several centers and to establish a clear line of authority and responsibility for decision making. The second purpose of this core is to utilize the facilities of the Clinical Trials Coordination Center (CTCC) under the direction of Dr. Kieburtz to provide data management for Projects 1, 2 and 3. The third critical function is to provide biostatistics support for all three projects through the active participation of Dr. McDermott, the project's chief Biostatistician, in all phases of study planning, execution and analysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS036519-05
Application #
6573420
Study Section
Project Start
2002-02-01
Project End
2003-01-31
Budget Start
Budget End
Support Year
5
Fiscal Year
2002
Total Cost
$282,412
Indirect Cost

  Institution

Name
Children's Memorial Hospital (Chicago)
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Wu, Y; Storey, P; Carrillo, A et al. (2008) Whole brain and localized magnetization transfer measurements are associated with cognitive impairment in patients infected with human immunodeficiency virus. AJNR Am J Neuroradiol 29:140-5
Sevigny, Jeffrey J; Albert, Steven M; McDermott, Michael P et al. (2007) An evaluation of neurocognitive status and markers of immune activation as predictors of time to death in advanced HIV infection. Arch Neurol 64:97-102
Wong, M H; Robertson, K; Nakasujja, N et al. (2007) Frequency of and risk factors for HIV dementia in an HIV clinic in sub-Saharan Africa. Neurology 68:350-5
Ragin, A B; Wu, Y; Storey, P et al. (2006) Monocyte chemoattractant protein-1 correlates with subcortical brain injury in HIV infection. Neurology 66:1255-7
Ragin, A B; Wu, Y; Storey, P et al. (2006) Bone marrow diffusion measures correlate with dementia severity in HIV patients. AJNR Am J Neuroradiol 27:589-92
Herrmann, D N; McDermott, M P; Sowden, J E et al. (2006) Is skin biopsy a predictor of transition to symptomatic HIV neuropathy? A longitudinal study. Neurology 66:857-61
Schifitto, G; McDermott, M P; McArthur, J C et al. (2005) Markers of immune activation and viral load in HIV-associated sensory neuropathy. Neurology 64:842-8
Ragin, Ann B; Wu, Ying; Storey, Pippa et al. (2005) Diffusion tensor imaging of subcortical brain injury in patients infected with human immunodeficiency virus. J Neurovirol 11:292-8
Sacktor, Ned C; Wong, Matthew; Nakasujja, Noeline et al. (2005) The International HIV Dementia Scale: a new rapid screening test for HIV dementia. AIDS 19:1367-74
Andrade, Adriana S A; McGruder, Henraya F; Wu, Albert W et al. (2005) A programmable prompting device improves adherence to highly active antiretroviral therapy in HIV-infected subjects with memory impairment. Clin Infect Dis 41:875-82

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