Abstract

The purpose of this Core is to make available transgenic and knockout mutants for Projects 1 and 3 of the program. One particular strength of this Transgenic Animal Core is that Dr. Chan (Core Leader) will provide his expertise in the use of superoxide dismutase, transgenic and knockout mutant mice, as well as oxygen radical-related biochemistry and molecular biology to the other projects, including 1 and 3. In addition, this Core will provide our expertise in molecular analysis of gene expression (PCR, RT-PCR) and gel electrophoresis for enzyme activities of CuZnSOD and MnSOD in mice and rats. Thus, this Transgenic Animal Core provides a unique vehicle for the projects to achieve their research goals with various transgenic and knockout animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS037520-03
Application #
6480801
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2001-03-01
Project End
2002-02-28
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
2001
Total Cost
$155,764
Indirect Cost

  Institution

Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Knowland, Daniel; Arac, Ahmet; Sekiguchi, Kohei J et al. (2014) Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke. Neuron 82:603-17
Arac, Ahmet; Grimbaldeston, Michele A; Nepomuceno, Andrew R B et al. (2014) Evidence that meningeal mast cells can worsen stroke pathology in mice. Am J Pathol 184:2493-504
Daadi, Marcel M; Hu, Shijun; Klausner, Jill et al. (2013) Imaging neural stem cell graft-induced structural repair in stroke. Cell Transplant 22:881-92
Cheng, Michelle Y; Lee, Alex G; Culbertson, Collin et al. (2012) Prokineticin 2 is an endangering mediator of cerebral ischemic injury. Proc Natl Acad Sci U S A 109:5475-80
Horie, Nobutaka; Pereira, Marta P; Niizuma, Kuniyasu et al. (2011) Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation, and vascular repair. Stem Cells 29:274-85
Andres, Robert H; Horie, Nobutaka; Slikker, William et al. (2011) Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain. Brain 134:1777-89
Andres, Robert H; Choi, Raymond; Pendharkar, Arjun V et al. (2011) The CCR2/CCL2 interaction mediates the transendothelial recruitment of intravascularly delivered neural stem cells to the ischemic brain. Stroke 42:2923-31
Cheng, Michelle Y; Lee, I-Ping; Jin, Michael et al. (2011) An insult-inducible vector system activated by hypoxia and oxidative stress for neuronal gene therapy. Transl Stroke Res 2:92-100
Arac, Ahmet; Brownell, Sara E; Rothbard, Jonathan B et al. (2011) Systemic augmentation of alphaB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation. Proc Natl Acad Sci U S A 108:13287-92
Encarnacion, Angelo; Horie, Nobutaka; Keren-Gill, Hadar et al. (2011) Long-term behavioral assessment of function in an experimental model for ischemic stroke. J Neurosci Methods 196:247-57

Showing the most recent 10 out of 117 publications