The Biostatistics and Modeling core will provide services to each of the proposed Projects. In Project 1, the statistical core will have responsibility for the analysis of the clinical studies where complex analysis models are proposed. Of special importance in this project will be the development of the dynamic linear model and analyses of the data from clinical trial. In Project 2, statistical consulting will primarily focus on a review of the analyses performed by the principal investigators and for the performance of any complex analyses, as needed. A similar role will be met for Project 3. The dynamic linear model method of analysis of data obtained from the continuous monitoring of patients in the Neurosurgical Intensive Care Unit will be developed in this Core. Reference analyses of data obtained during the clinical trial described in the Overview will be performed to generate prior distributions for use in subsequent models. The development of a time-varying discount parameter will be performed and tested using these data. Several alternative formulations of the model will also be tested. A comparison of performance these models will be performed using data collected during the first two years of this grant period. The model which provides the best characterization of change in jugular oxygen saturation an which is most highly correlated with the dynamic measures of autoregulation will then be used in the following three years to validate the model. Mathematical model of cerebral blood flow and gas transport dynamic will be performed in this Core. These models will initially focus on the rat cerebral blood flow, and will have direct application to project 3. Once a satisfactory model is obtained for the rat, similar models will be constructed to reflect the data obtained from human studies. These models will be refined against the data obtained in Project 1. Additionally, the data obtained in Project 2 will provide information for the modeling of the control of vascular resistance and capacitance.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Program Projects (P01)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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Baylor College of Medicine
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Rubin, Maria Laura; Chan, Wenyaw; Yamal, Jose-Miguel et al. (2017) A joint logistic regression and covariate-adjusted continuous-time Markov chain model. Stat Med 36:4570-4582
Aisiku, Imoigele P; Yamal, Jose-Miguel; Doshi, Pratik et al. (2016) The incidence of ARDS and associated mortality in severe TBI using the Berlin definition. J Trauma Acute Care Surg 80:308-12
Aisiku, Imo P; Yamal, Jose-Miguel; Doshi, Pratik et al. (2016) Plasma cytokines IL-6, IL-8, and IL-10 are associated with the development of acute respiratory distress syndrome in patients with severe traumatic brain injury. Crit Care 20:288
Vedantam, Aditya; Yamal, Jose-Miguel; Rubin, Maria Laura et al. (2016) Progressive hemorrhagic injury after severe traumatic brain injury: effect of hemoglobin transfusion thresholds. J Neurosurg 125:1229-1234
Lazaridis, Christos; Yang, Ming; DeSantis, Stacia M et al. (2015) Predictors of intensive care unit length of stay and intracranial pressure in severe traumatic brain injury. J Crit Care 30:1258-62
Yamal, José-Miguel; Benoit, Julia S; Doshi, Pratik et al. (2015) Association of transfusion red blood cell storage age and blood oxygenation, long-term neurologic outcome, and mortality in traumatic brain injury. J Trauma Acute Care Surg 79:843-9
Yamal, Jose-Miguel; Rubin, M Laura; Benoit, Julia S et al. (2015) Effect of Hemoglobin Transfusion Threshold on Cerebral Hemodynamics and Oxygenation. J Neurotrauma 32:1239-45
Yamal, Jose-Miguel; Robertson, Claudia S; Rubin, M Laura et al. (2014) Enrollment of racially/ethnically diverse participants in traumatic brain injury trials: effect of availability of exception from informed consent. Clin Trials 11:187-94
Robertson, Claudia S; Yamal, Jose-Miguel; Tilley, Barbara C (2014) Erythropoietin for traumatic brain injury--reply. JAMA 312:1929
Robertson, Claudia S; Hannay, H Julia; Yamal, José-Miguel et al. (2014) Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. JAMA 312:36-47

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