Abstract

The Analytical and Neuropathology Core provides analytical neurochemistry, gross and microscopicpathology, and tissue, CSF and microdialysate banking for the Program Project.
The Specific Aims are: 1.)measure nitrate/nitrite as markers of nitric oxide metabolism in humans and animals following traumatic braininjury (TBI) and in response to erythropoietin (Epo) administration following TBI. 2.) measure Epo and Eporeceptor following TBI in humans and animals. 3.) measure biomarkers of inflammation in microdialysateand CSF samples following TBI and in response to Epo therapy. 4.) provide neuropathology support forhistopathological analysis of experimental TBI including measurement of contusion volumes, neuronal loss,and antigen expression. 5.) provide tissue and CSF, serum, and microdialysate sample banking for animaland human tissue samples from TBI. 6.) provide analysis of arachidonic acid conversion to epoxygenaseproducts by P450 following TBI in experimental animals. As in previous iterations of the Program Project,the Analytical and Neuropathology Core interacts closely with the major scientific projects and with the othercores.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
2P01NS038660-06A2
Application #
7018088
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2006-03-15
Project End
2011-01-31
Budget Start
2006-03-15
Budget End
2007-01-31
Support Year
6
Fiscal Year
2006
Total Cost
$133,448
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Rubin, Maria Laura; Chan, Wenyaw; Yamal, Jose-Miguel et al. (2017) A joint logistic regression and covariate-adjusted continuous-time Markov chain model. Stat Med 36:4570-4582
Aisiku, Imoigele P; Yamal, Jose-Miguel; Doshi, Pratik et al. (2016) The incidence of ARDS and associated mortality in severe TBI using the Berlin definition. J Trauma Acute Care Surg 80:308-12
Aisiku, Imo P; Yamal, Jose-Miguel; Doshi, Pratik et al. (2016) Plasma cytokines IL-6, IL-8, and IL-10 are associated with the development of acute respiratory distress syndrome in patients with severe traumatic brain injury. Crit Care 20:288
Vedantam, Aditya; Yamal, Jose-Miguel; Rubin, Maria Laura et al. (2016) Progressive hemorrhagic injury after severe traumatic brain injury: effect of hemoglobin transfusion thresholds. J Neurosurg 125:1229-1234
Lazaridis, Christos; Yang, Ming; DeSantis, Stacia M et al. (2015) Predictors of intensive care unit length of stay and intracranial pressure in severe traumatic brain injury. J Crit Care 30:1258-62
Yamal, José-Miguel; Benoit, Julia S; Doshi, Pratik et al. (2015) Association of transfusion red blood cell storage age and blood oxygenation, long-term neurologic outcome, and mortality in traumatic brain injury. J Trauma Acute Care Surg 79:843-9
Yamal, Jose-Miguel; Rubin, M Laura; Benoit, Julia S et al. (2015) Effect of Hemoglobin Transfusion Threshold on Cerebral Hemodynamics and Oxygenation. J Neurotrauma 32:1239-45
Yamal, Jose-Miguel; Robertson, Claudia S; Rubin, M Laura et al. (2014) Enrollment of racially/ethnically diverse participants in traumatic brain injury trials: effect of availability of exception from informed consent. Clin Trials 11:187-94
Robertson, Claudia S; Yamal, Jose-Miguel; Tilley, Barbara C (2014) Erythropoietin for traumatic brain injury--reply. JAMA 312:1929
Robertson, Claudia S; Hannay, H Julia; Yamal, José-Miguel et al. (2014) Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. JAMA 312:36-47

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