Abstract

used): This Core will provide technical support for in vivo experiments proposed in the PPG. The Core will apply rat and mouse models of spinal cord injury (SCI) using an NYU Impactor to assist in the conduction of in vivo studies proposed in Projects 3 and 4. The majors goals of Core C are to establish and maintain rodent SCI models for animals studies; to implement and execute in vivo experimental protocol proposed by PPG investigators; and to assess changes in functional outcomes following interventions administered by PPG investigators. The overall objective of this Core is to support PPG investigators in conducting in vivo experiments and in determining the efficacy of ES cell transplantation for improving functional recovery after SCI.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
1P01NS039577-01
Application #
6326697
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
1999-12-17
Project End
2004-11-30
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
$175,256
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Vadivelu, Sudhakar; Stewart, Todd J; Qu, Yun et al. (2015) NG2+ progenitors derived from embryonic stem cells penetrate glial scar and promote axonal outgrowth into white matter after spinal cord injury. Stem Cells Transl Med 4:401-11
Becker, Daniel; Gary, Devin S; Rosenzweig, Ephron S et al. (2010) Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats. Exp Neurol 222:211-8
Cui, Lin; Jiang, Jun; Wei, Ling et al. (2008) Transplantation of embryonic stem cells improves nerve repair and functional recovery after severe sciatic nerve axotomy in rats. Stem Cells 26:1356-65
Dilmanian, F Avraham; Qu, Yun; Feinendegen, Ludwig E et al. (2007) Tissue-sparing effect of x-ray microplanar beams particularly in the CNS: is a bystander effect involved? Exp Hematol 35:69-77
Huettner, James E; Lu, Aiwu; Qu, Yun et al. (2006) Gap junctions and connexon hemichannels in human embryonic stem cells. Stem Cells 24:1654-67
Vadivelu, Sudhakar; Platik, Marina M; Choi, Luke et al. (2005) Multi-germ layer lineage central nervous system repair: nerve and vascular cell generation by embryonic stem cells transplanted in the injured brain. J Neurosurg 103:124-35
Vadivelu, Sudhakar; Becker, Daniel; McDonald, John W (2005) Generating chimeric spinal cord: a novel model for transplantable oligodendrocyte progenitors derived from embryonic stem cells. Neurosurg Focus 19:E3
Wei, Ling; Cui, Lin; Snider, B Joy et al. (2005) Transplantation of embryonic stem cells overexpressing Bcl-2 promotes functional recovery after transient cerebral ischemia. Neurobiol Dis 19:183-93
Xian, Hai-Qing; Werth, Kelly; Gottlieb, David I (2005) Promoter analysis in ES cell-derived neural cells. Biochem Biophys Res Commun 327:155-62
Lee, Chul-Sang; Tee, Lee Y; Dusenbery, Susan et al. (2005) Neurotrophin and GDNF family ligands promote survival and alter excitotoxic vulnerability of neurons derived from murine embryonic stem cells. Exp Neurol 191:65-76

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