Abstract

use) Project IV will study the integration of transplanted ESNLCs into injured spinal circuits. By the use of conventional physiological and anatomical tools, recovery produced by ESNLC transplants will be assessed in well-characterized spinal circuits. Specifically, the recovery myotactic reflex will be correlated with the recovery of bulbospinal, substrates for transplant induced recovery of bulbospinal, propriospinal and muscle afferent projections to the spinal cord. The circuit substrates for transplant-induced recovery of function will also be evaluated, apoptosis. The project will rely on the Injury/Animal CORE C for animal closely work with the other Projects and Cores to relate physiological and anatomical substrates of recovery with the behavioral effects of an optimal ESNLC treatment strategy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS039577-03
Application #
6565295
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
3
Fiscal Year
2002
Total Cost
$175,259
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Vadivelu, Sudhakar; Stewart, Todd J; Qu, Yun et al. (2015) NG2+ progenitors derived from embryonic stem cells penetrate glial scar and promote axonal outgrowth into white matter after spinal cord injury. Stem Cells Transl Med 4:401-11
Becker, Daniel; Gary, Devin S; Rosenzweig, Ephron S et al. (2010) Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats. Exp Neurol 222:211-8
Cui, Lin; Jiang, Jun; Wei, Ling et al. (2008) Transplantation of embryonic stem cells improves nerve repair and functional recovery after severe sciatic nerve axotomy in rats. Stem Cells 26:1356-65
Dilmanian, F Avraham; Qu, Yun; Feinendegen, Ludwig E et al. (2007) Tissue-sparing effect of x-ray microplanar beams particularly in the CNS: is a bystander effect involved? Exp Hematol 35:69-77
Huettner, James E; Lu, Aiwu; Qu, Yun et al. (2006) Gap junctions and connexon hemichannels in human embryonic stem cells. Stem Cells 24:1654-67
Vadivelu, Sudhakar; Platik, Marina M; Choi, Luke et al. (2005) Multi-germ layer lineage central nervous system repair: nerve and vascular cell generation by embryonic stem cells transplanted in the injured brain. J Neurosurg 103:124-35
Vadivelu, Sudhakar; Becker, Daniel; McDonald, John W (2005) Generating chimeric spinal cord: a novel model for transplantable oligodendrocyte progenitors derived from embryonic stem cells. Neurosurg Focus 19:E3
Wei, Ling; Cui, Lin; Snider, B Joy et al. (2005) Transplantation of embryonic stem cells overexpressing Bcl-2 promotes functional recovery after transient cerebral ischemia. Neurobiol Dis 19:183-93
Xian, Hai-Qing; Werth, Kelly; Gottlieb, David I (2005) Promoter analysis in ES cell-derived neural cells. Biochem Biophys Res Commun 327:155-62
Lee, Chul-Sang; Tee, Lee Y; Dusenbery, Susan et al. (2005) Neurotrophin and GDNF family ligands promote survival and alter excitotoxic vulnerability of neurons derived from murine embryonic stem cells. Exp Neurol 191:65-76

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