Core - Imaging

Van Vactor, David L.

Abstract

The imaging core will provide microscopy services to all three projects. The facilities for this core will be in two locations. The confocal and standard fluorescence microscopy facilities will be located at HIM. The real-time fluorescence imaging facility, along with tissue sectioning and histological facilities will be located in the HMS building with the labs of Drs. Van Vactor and Flanagan. The core will be jointly administered by the PIs with Dr Van Vactor directly supervising the Research Assistant maintaining the facility. Monies are requested for this assistant, supplies and a real-time imaging system.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Research Program Projects (P01)
• Project #: 5P01NS040043-03
• Application #: 6664657
• Study Section: National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
• Project Start: 2002-06-01
• Project End: 2003-05-31
• Support Year: 3
• Fiscal Year: 2002

Institution

• Name: Beth Israel Deaconess Medical Center
• DUNS #: 076593722
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02215

Publications

Liu, Judy S; Schubert, Christian R; Fu, Xiaoqin et al. (2012) Molecular basis for specific regulation of neuronal kinesin-3 motors by doublecortin family proteins. Mol Cell 47:707-21

Tcherkezian, Joseph; Brittis, Perry A; Thomas, Franziska et al. (2010) Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell 141:632-44

Kim, Seonhee; Lehtinen, Maria K; Sessa, Alessandro et al. (2010) The apical complex couples cell fate and cell survival to cerebral cortical development. Neuron 66:69-84

Loya, Carlos M; Van Vactor, David; Fulga, Tudor A (2010) Understanding neuronal connectivity through the post-transcriptional toolkit. Genes Dev 24:625-35

Loya, Carlos M; Lu, Cecilia S; Van Vactor, David et al. (2009) Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms. Nat Methods 6:897-903

Neal, Jason; Takahashi, Masaya; Silva, Matthew et al. (2007) Insights into the gyrification of developing ferret brain by magnetic resonance imaging. J Anat 210:66-77

Lu, Jie; Lian, Gewei; Lenkinski, Robert et al. (2007) Filamin B mutations cause chondrocyte defects in skeletal development. Hum Mol Genet 16:1661-75

Sheen, Volney L; Ferland, Russell J; Harney, Megan et al. (2006) Impaired proliferation and migration in human Miller-Dieker neural precursors. Ann Neurol 60:137-44

Olson, Eric C; Kim, Seonhee; Walsh, Christopher A (2006) Impaired neuronal positioning and dendritogenesis in the neocortex after cell-autonomous Dab1 suppression. J Neurosci 26:1767-75

Sheen, Volney L; Ferland, Russell J; Neal, Jason et al. (2006) Neocortical neuronal arrangement in Miller Dieker syndrome. Acta Neuropathol 111:489-96