Abstract

The Core Histology facility for this Program will provide the technical and pathological expertise for all tissue preparation for the 5 projects. These projects are heavily dependent on experimental animals with pathological endpoints. High quality preparation is necessary for quantitative studies, as well as for studies requiring identification of structures located deep within tissues. With the Histology Core in place, equipment and supply duplication will be minimized, and economies of scale will be realized. Quality control will also benefit from a central dedicated facility.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS040405-03
Application #
6645015
Study Section
Special Emphasis Panel (ZNS1)
Project Start
2002-07-01
Project End
2003-06-30
Budget Start
Budget End
Support Year
3
Fiscal Year
2002
Total Cost
$55,741
Indirect Cost

  Institution

Name
Emory University
Department
Type
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Livingston, Beven P; Nichols, T Richard (2014) Effects of reinnervation of the triceps brachii on joint kinematics and electromyographic patterns of the feline forelimb during level and upslope walking. Cells Tissues Organs 199:405-22
Livingston, Beven P; Nichols, T Richard (2014) Effects of reinnervation of the biarticular shoulder-elbow muscles on joint kinematics and electromyographic patterns of the feline forelimb during downslope walking. Cells Tissues Organs 199:423-40
Conforti, L; Fang, G; Beirowski, B et al. (2007) NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration. Cell Death Differ 14:116-27
Rich, Mark M; Wenner, Peter (2007) Sensing and expressing homeostatic synaptic plasticity. Trends Neurosci 30:119-25
Rich, Mark M (2006) The control of neuromuscular transmission in health and disease. Neuroscientist 12:134-42
Wang, Xueyong; Engisch, Kathrin L; Teichert, Russell W et al. (2006) Prolongation of evoked and spontaneous synaptic currents at the neuromuscular junction after activity blockade is caused by the upregulation of fetal acetylcholine receptors. J Neurosci 26:8983-7
Wang, Xueyong; Li, Yingjie; Engisch, Kathrin L et al. (2005) Activity-dependent presynaptic regulation of quantal size at the mammalian neuromuscular junction in vivo. J Neurosci 25:343-51
Nichols, T Richard; Cope, Timothy C (2004) Cross-bridge mechanisms underlying the history-dependent properties of muscle spindles and stretch reflexes. Can J Physiol Pharmacol 82:569-76
Fischer, Lindsey R; Culver, Deborah G; Tennant, Philip et al. (2004) Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp Neurol 185:232-40
Haftel, Valerie K; Bichler, Edyta K; Nichols, T Richard et al. (2004) Movement reduces the dynamic response of muscle spindle afferents and motoneuron synaptic potentials in rat. J Neurophysiol 91:2164-71

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