Abstract

Core B provides the cells to be employed for treatment as well as the essential outcome measurements for all constituent projects of the Program Project. Neurologic function and behavior are the primary outcome measures for Project 1 (Treatment of Stroke with MSCs) Project 2 (Treatment of Traumatic Brain Injury with MSCs) and are extensively employed in Project 3 (Analysis of MSC Interaction with Tissue). In this core, we describe the sets of functional tests to be employed in evaluating response to MSC therapy. Included in the battery of tests are, motor and somatosensory tests, and neurological scales. Projects 1-3 also address the fate of the injected MSCs, the factors produced by these cells and their effect on cerebral tissue that promote improved functional outcome, and the effects of MSCs on the endogenous parenchymal cells. This core provides all the resources required for cellular identification, measurement and identification of trophic factors, and microscopy. All three projects employ marrow stromal cells. Core B, provides the facilities and personnel dedicated to the production and characterization of these cells. Focusing resources needed for the component projects in Core B, allows for efficient and effective utilization of resources essential for all three projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS042345-04
Application #
7553693
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
4
Fiscal Year
2006
Total Cost
$249,085
Indirect Cost

  Institution

Name
Henry Ford Health System
Department
Type
DUNS #
073134603
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Ding, Guang-Liang; Chopp, Michael; Li, Lian et al. (2014) Magnetic Resonance Imaging of Stroke in the Rat. Bo Pu Xue Za Zhi 31:116-132
Darwish, Hala; Mahmood, Asim; Schallert, Timothy et al. (2014) Simvastatin and environmental enrichment effect on recognition and temporal order memory after mild-to-moderate traumatic brain injury. Brain Inj 28:211-26
Xiong, Ye; Mahmood, Asim; Chopp, Michael (2013) Animal models of traumatic brain injury. Nat Rev Neurosci 14:128-42
Xiong, Ye; Mahmood, Asim; Meng, Yuling et al. (2012) Neuroprotective and neurorestorative effects of thymosin ?4 treatment following experimental traumatic brain injury. Ann N Y Acad Sci 1270:51-8
Darwish, Hala; Dawish, Hala; Mahmood, Asim et al. (2012) Mild traumatic brain injury (MTBI) leads to spatial learning deficits. Brain Inj 26:151-65
Meng, Yuling; Xiong, Ye; Mahmood, Asim et al. (2011) Dose-dependent neurorestorative effects of delayed treatment of traumatic brain injury with recombinant human erythropoietin in rats. J Neurosurg 115:550-60
Santra, Manoranjan; Santra, Sutapa; Buller, Ben et al. (2011) Effect of doublecortin on self-renewal and differentiation in brain tumor stem cells. Cancer Sci 102:1350-7
Li, Lian; Jiang, Quan; Qu, Chang Sheng et al. (2011) Transplantation of marrow stromal cells restores cerebral blood flow and reduces cerebral atrophy in rats with traumatic brain injury: in vivo MRI study. J Neurotrauma 28:535-45
Xiong, Ye; Mahmood, Asim; Zhang, Yanlu et al. (2011) Effects of posttraumatic carbamylated erythropoietin therapy on reducing lesion volume and hippocampal cell loss, enhancing angiogenesis and neurogenesis, and improving functional outcome in rats following traumatic brain injury. J Neurosurg 114:549-59
Shen, Li Hong; Xin, Hongqi; Li, Yi et al. (2011) Endogenous tissue plasminogen activator mediates bone marrow stromal cell-induced neurite remodeling after stroke in mice. Stroke 42:459-64

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