The Clinical Core was founded in 1992 under the auspices of a previous Program Project as the most efficient mechanism for recruiting, evaluating and referring subjects to the Program's human subjects investigations and for establishing and managing a permanent database of clinical, demographic, and psychosocial information on patients and controls for use by the investigators. A biometric section will be incorporated in this core in the upcoming funding period. The core will continue subject management, quarterly contacts with enrolled subjects, and web-based data collection to support the ongoing, longitudinal prospective study of risk factors in the development of TMD (Subproject by Maixner). In addition the core will be responsible for the recruitment of, and database creation and management of subjects participating in all the Pain Mechanisms Studies of Subprojects by Maixner, Hollins, and Essick. Accordingly, the specific aims and function of this core are to: 1. Recruit and confirm a diagnosis for TMD patients, fibromyalgia (FM) patients, and healthy subjects. A phone screening for exclusion criteria will precede a screening visit that will include a medical history and diagnostic physical exam by a health care professional, as well as completion of demographic and health history questionnaires. 2. Coordinate subjects' participation in the human studies by scheduling screening visits and testing sessions in Subprojects by Maixner, Hollins, and Essick; by randomizing subjects to testing protocol, where appropriate; and by monitoring compliance with protocols. 3. For Subproject by Maixner, coordinate randomization and dispensing the beta-adrenergic blockade agent and placebo; and monitor subjects for drug side effects. 4. Oversee data collection, entry, processing, storage, and distribution to the investigators from patients and healthy subjects relevant to their research inquiries. 5. Assist investigators in designing and implementing plans for statistical analyses of research data, and in the interpretation of results.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
1P01NS045685-01A2
Application #
6876998
Study Section
Special Emphasis Panel (ZNS1-SRB-A (20))
Project Start
2004-12-01
Project End
2009-06-30
Budget Start
2004-12-01
Budget End
2005-06-30
Support Year
1
Fiscal Year
2004
Total Cost
$312,449
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Zhang, Xin; Hartung, Jane E; Bortsov, Andrey V et al. (2018) Sustained stimulation of ?2- and ?3-adrenergic receptors leads to persistent functional pain and neuroinflammation. Brain Behav Immun 73:520-532
Sigurdsson, Martin I; Waldron, Nathan H; Bortsov, Andrey V et al. (2018) Genomics of Cardiovascular Measures of Autonomic Tone. J Cardiovasc Pharmacol 71:180-191
Kim, Seungtae; Zhang, Xin; O'Buckley, Sandra C et al. (2018) Acupuncture Resolves Persistent Pain and Neuroinflammation in a Mouse Model of Chronic Overlapping Pain Conditions. J Pain 19:1384.e1-1384.e14
Smith, Shad B; Parisien, Marc; Bair, Eric et al. (2018) Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males. Pain :
Suarez-Roca, Heberto; Klinger, Rebecca Y; Podgoreanu, Mihai V et al. (2018) Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes. Anesthesiology :
Moss, Chailee F; Damitz, Lynn A; Gracely, Richard H et al. (2016) Dorsal clitoral nerve injury following transobturator midurethral sling. J Pain Res 9:727-730
Wu, Cindy; Damitz, Lynn; Karrat, Kimberly M et al. (2016) Clitoral Epidermal Inclusion Cyst Resection With Intraoperative Sensory Nerve Mapping Technique. Female Pelvic Med Reconstr Surg 22:e24-6
Maixner, William; Fillingim, Roger B; Williams, David A et al. (2016) Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification. J Pain 17:T93-T107
Ciszek, Brittney P; O'Buckley, Sandra C; Nackley, Andrea G (2016) Persistent Catechol-O-methyltransferase-dependent Pain Is Initiated by Peripheral ?-Adrenergic Receptors. Anesthesiology 124:1122-35
Oladosu, Folabomi A; Ciszek, Brittney P; O'Buckley, Sandra C et al. (2016) Novel intrathecal and subcutaneous catheter delivery systems in the mouse. J Neurosci Methods 264:119-128

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