The psychophysical research proposed in this subproject will examine three types of sensory interactions involving pain -- touch gating, pain gating, and diffuse noxious inhibitory controls (DNIC) -- in normal subjects, and in patients with fibromyalgia (FM) and temporomandibular disorders (TMD). The etiology of these two chronic-pain conditions is obscure, but their symptomatology includes evidence of a centrally mediated enhancement of sensitivity to noxious stimuli. The proposed research explores the possibility that disturbances of pain gate and DNIC contribute to the magnitude of this enhancement, and that touch gate can serve as an index of its severity. Major goals of the research are to analyze the ways in which these sensory interactions vary as a function of clinical status, the extent to which their strengths are statistically related across individuals, and their degree of association with hypervigilance, as indexed by detail of pain report and other measures. Forced-choice measurement of detection and discrimination thresholds will be used to explore impairments of vibrotaction produced by pain (usually attributed to a """"""""touch gate""""""""): These experiments will reveal whether experimental and clinical pain have comparable effects on the touch gate, and whether, in FM as in TMD, frequency discrimination is impaired more than other measures of vibrotaction. Visual analog scaling will be used to examine the effects of vibratory stimulation on pain intensity (pain gating), and the way in which this form of interaction depends on vibration frequency. DNIC will be studied both in the context of its ability to suppress slowly increasing (C-fiber mediated) pain, and to block the temporal summation associated with wind-up.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS045685-05
Application #
7658747
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
5
Fiscal Year
2008
Total Cost
$212,622
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Zhang, Xin; Hartung, Jane E; Bortsov, Andrey V et al. (2018) Sustained stimulation of ?2- and ?3-adrenergic receptors leads to persistent functional pain and neuroinflammation. Brain Behav Immun 73:520-532
Sigurdsson, Martin I; Waldron, Nathan H; Bortsov, Andrey V et al. (2018) Genomics of Cardiovascular Measures of Autonomic Tone. J Cardiovasc Pharmacol 71:180-191
Kim, Seungtae; Zhang, Xin; O'Buckley, Sandra C et al. (2018) Acupuncture Resolves Persistent Pain and Neuroinflammation in a Mouse Model of Chronic Overlapping Pain Conditions. J Pain 19:1384.e1-1384.e14
Smith, Shad B; Parisien, Marc; Bair, Eric et al. (2018) Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males. Pain :
Suarez-Roca, Heberto; Klinger, Rebecca Y; Podgoreanu, Mihai V et al. (2018) Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes. Anesthesiology :
Moss, Chailee F; Damitz, Lynn A; Gracely, Richard H et al. (2016) Dorsal clitoral nerve injury following transobturator midurethral sling. J Pain Res 9:727-730
Wu, Cindy; Damitz, Lynn; Karrat, Kimberly M et al. (2016) Clitoral Epidermal Inclusion Cyst Resection With Intraoperative Sensory Nerve Mapping Technique. Female Pelvic Med Reconstr Surg 22:e24-6
Maixner, William; Fillingim, Roger B; Williams, David A et al. (2016) Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification. J Pain 17:T93-T107
Ciszek, Brittney P; O'Buckley, Sandra C; Nackley, Andrea G (2016) Persistent Catechol-O-methyltransferase-dependent Pain Is Initiated by Peripheral ?-Adrenergic Receptors. Anesthesiology 124:1122-35
Oladosu, Folabomi A; Ciszek, Brittney P; O'Buckley, Sandra C et al. (2016) Novel intrathecal and subcutaneous catheter delivery systems in the mouse. J Neurosci Methods 264:119-128

Showing the most recent 10 out of 95 publications