The goal of the Bioinformatics Core (BC) will be to provide web-accessible annotation, cataloging facilities and state-of-the-art bioinformatics analyses. This will enable researchers from all three of the projects to maximally utilize the gene expression, polymorphism and proteomic data sets to determine functional dependencies among the known genes and Expressed Sequence Tags (ESTs) and direct further biological validation of these putative dependencies (the expression vector core addresses this critical biological validation step). The BC will connect data from in situ hybridization studies in project three to microarray centers using Affymetrix GeneChip arrays of human and murine expressed sequences. It will also integrate proteomic data and genotype data from the projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS047572-04
Application #
7426322
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
4
Fiscal Year
2007
Total Cost
$222,946
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
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