CORE B: Behavior Core - Dr. Jed Shumsky and Ms. Kassi Miller, Co-Directors All projects are proposing that rehabiitative therapy is beneficial to regeneration, repair and recovery of function. Behavior is often noted as the final common output of the CNS. It requires the complex coordination of anatomical substrates, molecular and electrophysiological signals of intact anatomical substrates to elucidate seemingly simple behavior like taking a step or discriminating betiween a light touch or a noxious pinch. Therefore, the sensitivity, validity and reliability of rehabilitative and behavioral testing techniques are critical not only to the success of individual projects, but also for the success and interpretation of the Program Project as a whole. The goal of the Behavior Core is to provide a central facility to the Pis to provide rehabilitative training and/or assess the functional significance of rehabilitative or cellular grafting interventions proposed by the Pis. The Behavior Core provides assistance with experimental design, a centralized facility that is outfitted with at least 7 standardized paradigms for rehabilitative training and more than 25 standardized behavioral testing procotols to test motor, sensorimotor, sensory and autonomic function in rodents and cats after spinal cord injury. Finally, the Behavior Core provides individualized hands- on technical training for technical staff, graduate students, postdoctoral fellows, faculty and visiting faculty in behavioral testing or rehabilitative strategies.

Public Health Relevance

The purpose of this PPG is to utilize regenerative and rehabilitative strategies to promote improvements in functional behavioral recovery. It is imperative that standardized rehabilitative and behavioral testing techniques are employed for accurate interpretation of results. The Behavior Core will provide standardized behavioral equipment and training for personnel to ensure reliability and validity of results.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
5P01NS055976-08
Application #
8828803
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
2015-04-01
Project End
2016-03-31
Budget Start
2015-04-01
Budget End
2016-03-31
Support Year
8
Fiscal Year
2015
Total Cost
$50,398
Indirect Cost
$17,778
Name
Drexel University
Department
Type
DUNS #
002604817
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Jin, Ying; Shumsky, Jed S; Fischer, Itzhak (2018) Axonal regeneration of different tracts following transplants of human glial restricted progenitors into the injured spinal cord in rats. Brain Res 1686:101-112
Zholudeva, Lyandysha V; Iyer, Nisha; Qiang, Liang et al. (2018) Transplantation of Neural Progenitors and V2a Interneurons after Spinal Cord Injury. J Neurotrauma 35:2883-2903
Chhaya, Soha J; Quiros-Molina, Daniel; Tamashiro-Orrego, Alessandra D et al. (2018) Exercise-Induced Changes to the Macrophage Response in the Dorsal Root Ganglia Prevent Neuropathic Pain after Spinal Cord Injury. J Neurotrauma :
Sahoo, Pabitra K; Smith, Deanna S; Perrone-Bizzozero, Nora et al. (2018) Axonal mRNA transport and translation at a glance. J Cell Sci 131:
Spruance, Victoria M; Zholudeva, Lyandysha V; Hormigo, Kristiina M et al. (2018) Integration of Transplanted Neural Precursors with the Injured Cervical Spinal Cord. J Neurotrauma 35:1781-1799
Zholudeva, Lyandysha V; Qiang, Liang; Marchenko, Vitaliy et al. (2018) The Neuroplastic and Therapeutic Potential of Spinal Interneurons in the Injured Spinal Cord. Trends Neurosci 41:625-639
Bezdudnaya, Tatiana; Hormigo, Kristiina M; Marchenko, Vitaliy et al. (2018) Spontaneous respiratory plasticity following unilateral high cervical spinal cord injury in behaving rats. Exp Neurol 305:56-65
Kar, Amar N; Lee, Seung Joon; Twiss, Jeffery L (2018) Expanding Axonal Transcriptome Brings New Functions for Axonally Synthesized Proteins in Health and Disease. Neuroscientist 24:111-129
Lane, Michael A; Lepore, Angelo C; Fischer, Itzhak (2017) Improving the therapeutic efficacy of neural progenitor cell transplantation following spinal cord injury. Expert Rev Neurother 17:433-440
Nair, Jayakrishnan; Bezdudnaya, Tatiana; Zholudeva, Lyandysha V et al. (2017) Histological identification of phrenic afferent projections to the spinal cord. Respir Physiol Neurobiol 236:57-68

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