Dr. Svendsen will have overall responsibility for directing the AdministrativeCore. Dr. Svendsen is specifically responsible for ensuring that regular research meetings are scheduled, i.e.the monthly meetings of the Pi's and senior group members, semiannual meetings of professional staff withthe Internal Advisory Committee, and annual meetings with the External Advisory Committee. He will leadthese meetings and moderate the discussions. These meetings, plus daily interactions among programscientists and staff, will ensure that vigorous scientific interactions are maintained within the program project.Dr. Svendsen will also ensure that scientific reports and continuation applications are written and submitted ina timely manner.A research manager to be appointed will assist Dr. Svendsen in the daily administration of the program. SueGilbert will be responsible for organizing meetings, keeping minutes, organizing travel and assisting withpublications. The financial administration of the program will be handled in the Waisman Center.A. RESOURCESa. LocationThis program project will be based at the Waisman Center. The laboratories of Doctors Mitchell, Zhang andSvendsen are all within close proximity to each other, thereby facilitating interactions and communication. Thefinancial administration will be handled in the Waisman Center.b. Office space and equipmentThe Waisman Center has available office space for the Research Manager and administrative support, as wellas basic computers, printers, and general supplies. However, we will need to purchase a new computer formanagement of the program project.B. RESEARCH PLANa. Authority of DirectorDr. Svendsen, as the program director, will be responsible for filing all progress reports and coordinating jointpublications arising from this work. He will ensure that the aims of each project are carried through and thatthe results are made available to each group through regular monthly meetings. He will work closely with theResearch Manager (yet to be named) and Sue Gilbert.PHS 398/2590 (Rev.09/04, Reissued 4/2006) Page 211 Continuation Format Page

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
1P01NS057778-01A1
Application #
7300529
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2007-09-01
Budget End
2008-03-31
Support Year
1
Fiscal Year
2007
Total Cost
$64,605
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Nichols, Nicole L; Satriotomo, Irawan; Allen, Latoya L et al. (2017) Mechanisms of Enhanced Phrenic Long-Term Facilitation in SOD1G93A Rats. J Neurosci 37:5834-5845
Nichols, Nicole L; Mitchell, Gordon S (2016) Quantitative assessment of integrated phrenic nerve activity. Respir Physiol Neurobiol 226:81-6
Jones, Jeffrey R; Zhang, Su-Chun (2016) Engineering human cells and tissues through pluripotent stem cells. Curr Opin Biotechnol 40:133-138
Chen, Hong; Qian, Kun; Chen, Wei et al. (2015) Human-derived neural progenitors functionally replace astrocytes in adult mice. J Clin Invest 125:1033-42
Nikodemova, Maria; Small, Alissa L; Smith, Stephanie M C et al. (2014) Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats. Neurobiol Dis 69:43-53
Gowing, Geneviève; Shelley, Brandon; Staggenborg, Kevin et al. (2014) Glial cell line-derived neurotrophic factor-secreting human neural progenitors show long-term survival, maturation into astrocytes, and no tumor formation following transplantation into the spinal cord of immunocompromised rats. Neuroreport 25:367-72
Dale, E A; Ben Mabrouk, F; Mitchell, G S (2014) Unexpected benefits of intermittent hypoxia: enhanced respiratory and nonrespiratory motor function. Physiology (Bethesda) 29:39-48
Nichols, N L; Johnson, R A; Satriotomo, I et al. (2014) Neither serotonin nor adenosine-dependent mechanisms preserve ventilatory capacity in ALS rats. Respir Physiol Neurobiol 197:19-28
Dale, Erica A; Mitchell, Gordon S (2013) Spinal vascular endothelial growth factor (VEGF) and erythropoietin (EPO) induced phrenic motor facilitation after repetitive acute intermittent hypoxia. Respir Physiol Neurobiol 185:481-8
Nichols, Nicole L; Van Dyke, J; Nashold, L et al. (2013) Ventilatory control in ALS. Respir Physiol Neurobiol 189:429-37

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