The Administrative Core (Core A) will provide coordination of scientific activities for the 3 projects and 3 cores. It will also facilitate daily operations and longer term planning for the individual and overall scientific program. Statistical consultation will also be available from the Core via Chengjie Xiong, a biostatistician. Core A has 2 aims.
Specific Aim 1. To facilitate communication, data sharing, and organize meefings between project leaders and our internal and external advisory boards. Dr. Xiong, as biostatistician, will provide statistical consultation for the projects and cores.
Specific Aim 2 : To assist in sharing PPG generated research with the general scientific and lay community as well as within and among PPG investigators.
Alzheimer's disease (AD) is the most common cause of dementia. There is no effective treatment that slows the progression of the disease. This core will provide an organizational structure for our efforts to better understand the relationship between cellular communication in the brain (synaptic activity) and the development of Alzheimer's disease.
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| Musiek, Erik S; Bhimasani, Meghana; Zangrilli, Margaret A et al. (2018) Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease. JAMA Neurol 75:582-590 |
| Kress, Geraldine J; Liao, Fan; Dimitry, Julie et al. (2018) Regulation of amyloid-? dynamics and pathology by the circadian clock. J Exp Med 215:1059-1068 |
| Ogaki, Kotaro; Martens, Yuka A; Heckman, Michael G et al. (2018) Multiple system atrophy and apolipoprotein E. Mov Disord 33:647-650 |
| Liao, Fan; Li, Aimin; Xiong, Monica et al. (2018) Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. J Clin Invest 128:2144-2155 |
| Kang, S S; Ren, Y; Liu, C-C et al. (2018) Lipocalin-2 protects the brain during inflammatory conditions. Mol Psychiatry 23:344-350 |
| Hettinger, Jane C; Lee, Hyo; Bu, Guojun et al. (2018) AMPA-ergic regulation of amyloid-? levels in an Alzheimer's disease mouse model. Mol Neurodegener 13:22 |
| Yuede, Carla M; Timson, Benjamin F; Hettinger, Jane C et al. (2018) Interactions between stress and physical activity on Alzheimer's disease pathology. Neurobiol Stress 8:158-171 |
| Liu, Chia-Chen; Hu, Jin; Zhao, Na et al. (2017) Astrocytic LRP1 Mediates Brain A? Clearance and Impacts Amyloid Deposition. J Neurosci 37:4023-4031 |
| Holth, Jerrah; Patel, Tirth; Holtzman, David M (2017) Sleep in Alzheimer's Disease - Beyond Amyloid. Neurobiol Sleep Circadian Rhythms 2:4-14 |
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