The Imaging Core supports the following Specific Aims ofthe three scientific projects ofthe Center for Brain Hemorrhage Research: 1) provide neuroimaging for edema (T2-weighted, T2W1), blood (T2WI and suscepribility weighted imaging, SWI), diffusion tensor imaging for white matter abnormalities, cerebral perfusion using both dynamic susceptibility contrast (DSC) and arterial spin labeling (ASL) approaches including cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) indices;2) undertake analysis for the collected imaging data, including anatomical mapping of edema and blood, blood brain barrier (BBB) disruption, white matter changes, cerebral perfusion abnormalities;3) provide a centralized location for Project Pi's and staff to access raw and analyzed datasets;4) develop and implement computational routines as we have for other disease states (i.e. stroke, TBI) to automate and speed analysis throughput, and 5) provide statistical and computational support for imaging data comparisons to behavior, cell biology and vascular outcomes. Our comprehensive approach will provide novel data about common interrelationships between three brain models of hemorrhagic injury, Subarachnoid Hemorrhage (SAH), Intracerebral Hemorrhage (ICH), and Traumatic Brain Injury (TBI). Clinical neuroimaging is increasingly taking a significant role in assessment of SAH, ICH, and TBI. A unifying feature of these neurological disease states is the deposition of extravascular blood which is extremely toxic to the brain and leads to rupture ofthe blood brain barrier (BBB). This cascade of events results in development of edema, often with catastrophic outcomes. Numerous studies have demonstrated that rapid imaging ofthe extent and anatomical location of blood is critical for decision-making relative to potential therapeutic interventions. Thus, the Imaging Core has elected for these Projects to focus on early and late indices of brain injury and function: 1) edema, 2) extravascular blood, 3) cerebral perfusion, and 4) white matter function. The Imaging Core will 1) undertake non-invasive but functional measures of brain physiology using MR imaging, 2) use standard and novel computational analysis to maximize data extraction, and 3) use numerical analysis methods to identify common data from all cores (Behavioral, Imaging, Vascular) that emerge for SAH, ICH, and TBI.

Public Health Relevance

The Imaging Core provides additional strengths that could not be obtained using traditional funding mechanisms and overall strengthens and unifies the overarching Aims ofthe Center for Brain Hemorrhage Research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Program Projects (P01)
Project #
1P01NS082184-01A1
Application #
8661428
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
1
Fiscal Year
2014
Total Cost
$204,421
Indirect Cost
$74,238
Name
Loma Linda University
Department
Type
DUNS #
009656273
City
Loma Linda
State
CA
Country
United States
Zip Code
92350
Manaenko, Anatol; Yang, Peng; Nowrangi, Derek et al. (2018) Inhibition of stress fiber formation preserves blood-brain barrier after intracerebral hemorrhage in mice. J Cereb Blood Flow Metab 38:87-102
Zhou, Keren; Enkhjargal, Budbazar; Xie, Zhiyi et al. (2018) Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat. Stroke 49:175-183
Xie, Zongyi; Huang, Lei; Enkhjargal, Budbazar et al. (2018) Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPAR?/NF?B signaling pathway after subarachnoid hemorrhage in rats. Brain Behav Immun 69:190-202
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Wu, Guangyong; McBride, Devin W; Zhang, John H (2018) Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-?B pathway after MCAO in rats. Neurobiol Dis 110:59-67
Xie, Zhiyi; Enkhjargal, Budbazar; Wu, Lingyun et al. (2018) Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats. Neuropharmacology 128:142-151

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