Abstract

The goal of this Core is to enhance the definition of phenotype by providing histopathologic expertise coupled with modern methods of histopathologic analyses. The expertise provided by this Core will insure the application of appropriate tissue preparation, preservation, and interpretation of histopathologic materials. An additional feature of this Core is that it will provide a cooperative effort between veterinary pathologists who characterize the mouse lesions and human pathologists who understand the subtleties of the human pathologies and therefore can fit the model to specific subtypes. The evaluation of qualitative and complex traits, a subject of some of the proposals in this program project grant (PPG) will also be enhanced by this approach.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Program Projects (P01)
Project #
5P01RR008911-06
Application #
6122953
Study Section
Project Start
1998-09-30
Project End
2000-09-29
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609

  Publications

Sundberg, John P; Silva, Kathleen A; Zhang, Weidong et al. (2009) Recombinant human hepatitis B vaccine initiating alopecia areata: testing the hypothesis using the C3H/HeJ mouse model. Vet Dermatol 20:99-104
Haskell, Bradford D; Flurkey, Kevin; Duffy, Theodore M et al. (2002) The diabetes-prone NZO/HlLt strain. I. Immunophenotypic comparison to the related NZB/BlNJ and NZW/LacJ strains. Lab Invest 82:833-42
Reifsnyder, Peter C; Leiter, Edward H (2002) Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice. Diabetes 51:825-32
Sundberg, J P; Boggess, D; Bascom, C et al. (2000) Lanceolate hair-J (lahJ): a mouse model for human hair disorders. Exp Dermatol 9:206-18
Leiter, E H; Kintner, J; Flurkey, K et al. (1999) Physiologic and endocrinologic characterization of male sex-biased diabetes in C57BLKS/J mice congenic for the fat mutation at the carboxypeptidease E locus. Endocrine 10:57-66
Ebert, D H; Bischof, L J; Streeper, R S et al. (1999) Structure and promoter activity of an islet-specific glucose-6-phosphatase catalytic subunit-related gene. Diabetes 48:543-51
Beamer, W G; Shultz, K L; Churchill, G A et al. (1999) Quantitative trait loci for bone density in C57BL/6J and CAST/EiJ inbred mice. Mamm Genome 10:1043-9
Leiter, E H; Reifsnyder, P C; Flurkey, K et al. (1998) NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds. Diabetes 47:1287-95
Kim, J H; Nishina, P M; Naggert, J K (1998) Genetic models for non insulin dependent diabetes mellitus in rodents. J Basic Clin Physiol Pharmacol 9:325-45
Fernandez-Salguero, P M; Ward, J M; Sundberg, J P et al. (1997) Lesions of aryl-hydrocarbon receptor-deficient mice. Vet Pathol 34:605-14

Showing the most recent 10 out of 18 publications