Abstract

The Core Unit will serve all of the projects on a highly interactive and collaborative basis. Four types of activities will be performed: 1. Animal Resource Management--The Core Unit will be responsible for all aspects of animal maintenance and health care, for carrying out animal pairing schedules, and for management of the animal records system. 2. Data Management and Analysis--The Core Unit will be responsible for management of detailed computerized life-history records on each animal, for management of experimental data associated with each animal (i.e., genotypic data, as well as phenotypic data related to cancer and lipoprotein endpoints), and for statistical analyses. Genetic analysis of data will also be carried out by the Core to test hypotheses regarding the role of genetic factors in UVR-induced lesion susceptibility. Research Support-The Core Unit will provide a variety of research services such as preparing special diets for research on lipoproteins, collecting and sorting blood and tissue samples from animals assigned to the various projects, conducting necropsies, and cooperating with the Department of Laboratory Animal Medicine (DLAM) in the provision of material for pathology services.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Program Projects (P01)
Project #
1P01RR009919-01
Application #
3767414
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Southwest Foundation for Biomedical Research
Department
Type
DUNS #
City
San Antonio
State
TX
Country
United States
Zip Code
78245

  Publications

Kammerer, Candace M; Rainwater, David L; Gouin, Nicolas et al. (2010) Localization of genes for V+LDL plasma cholesterol levels on two diets in the opossum Monodelphis domestica. J Lipid Res 51:2929-39
Samollow, Paul B; Kammerer, Candace M; Mahaney, Susan M et al. (2004) First-generation linkage map of the gray, short-tailed opossum, Monodelphis domestica, reveals genome-wide reduction in female recombination rates. Genetics 166:307-29
Wang, Z; Atencio, J; Robinson, E S et al. (2001) Ultraviolet B-induced melanoma in Monodelphis domestica occurs in the absence of alterations in the structure or expression of the p53 gene. Melanoma Res 11:239-45
Chan, J; Robinson, E S; Atencio, J et al. (2001) Characterization of the CDKN2A and ARF genes in UV-induced melanocytic hyperplasias and melanomas of an opossum (Monodelphis domestica). Mol Carcinog 31:16-26
Robinson, E S; Hill Jr, R H; Kripke, M L et al. (2000) The Monodelphis melanoma model: initial report on large ultraviolet A exposures of suckling young. Photochem Photobiol 71:743-6
Stone, W H; Brunn, D A; Foster, E B et al. (1998) Absence of a significant mixed lymphocyte reaction in a marsupial (Monodelphis domestica). Lab Anim Sci 48:184-9
Robinson, E S; Dooley, T P; Williams, K L (1998) UV-induced melanoma cell lines and their potential for proteome analysis: a review. J Exp Zool 282:48-53
Rainwater, D L (1998) Electrophoretic separation of LDL and HDL subclasses. Methods Mol Biol 110:137-51
Robinson, E S; Hubbard, G B; Colon, G et al. (1998) Low-dose ultraviolet exposure early in development can lead to widespread melanoma in the opossum model. Int J Exp Pathol 79:235-44
Stone, W H; Manis, G S; Hoffman, E S et al. (1997) Fate of allogeneic skin transplantations in a marsupial (Monodelphis domestica). Lab Anim Sci 47:283-7

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