The computational core will provide crucial support for all of the Projects and MRI Core. Support will be provided in the form of setting up and maintaining hardware and software tools for: * User interfaces for specifying goals * Data acquisition * Preprocessing/geometry creation/artifact reduction * Rendering techniques * Animation production/storage/dissemination * Atlas production/storage/dissemination * Computational infrastructure (disk backup, network maintenance, tools for software engineering, etc.) * Video network setup and operation * Software support and common tools for """"""""interoperability"""""""" between different computational environments (different workstations, PC's, Macs, specialized parallel computers, etc.) and digital image formats One of the main products of this Core will be an on-line digital archive of images, models, animations and data sets, and computational tools to use them. From this archive, we can produce 35mm slides, l6mm film, NTSC videotapes and CD-ROM data sets for dissemination and distribution. The disseminated media will be useful for a wide variety of research and teaching purposes, from anatomy to analysis. Computational tools and library production will initially be leveraged from a collection of existing hardware and software tools. These tools will be enhanced and integrated into a reliable software library.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory Grants (P20)
Project #
5P20DA008944-04
Application #
5209718
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Martin, Melanie; Hiltner, Timothy D; Wood, John C et al. (2006) Myelin deficiencies visualized in vivo: visually evoked potentials and T2-weighted magnetic resonance images of shiverer mutant and wild-type mice. J Neurosci Res 84:1716-26
Alauddin, Mian M; Louie, Angelique Y; Shahinian, Antranik et al. (2003) Receptor mediated uptake of a radiolabeled contrast agent sensitive to beta-galactosidase activity. Nucl Med Biol 30:261-5
Dhenain, Marc; Privat, Nicolas; Duyckaerts, Charles et al. (2002) Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images. NMR Biomed 15:197-203
Sendhil Velan, S; Narasimhan, P T; Jacobs, R E (2001) MR imaging with phase encoding of intermolecular multiple quantum coherences. J Magn Reson 152:189-94
Ahrens, E T; Dubowitz, D J (2001) Peripheral somatosensory fMRI in mouse at 11.7 T. NMR Biomed 14:318-24
Neusch, C; Rozengurt, N; Jacobs, R E et al. (2001) Kir4.1 potassium channel subunit is crucial for oligodendrocyte development and in vivo myelination. J Neurosci 21:5429-38
Holbrook, N M; Ahrens, E T; Burns, M J et al. (2001) In vivo observation of cavitation and embolism repair using magnetic resonance imaging. Plant Physiol 126:27-31
Dhenain, M; Ruffins, S W; Jacobs, R E (2001) Three-dimensional digital mouse atlas using high-resolution MRI. Dev Biol 232:458-70
Allman, J; Hasenstaub, A (1999) Brains, maturation times, and parenting. Neurobiol Aging 20:447-54