The Magnetic Resonance Core (MR Core) will provide support for the GABA measurement and Diffusion Tensor Imaging for all three Projects: the Animal Project and the two Clinical Projects. Having the Core provide this support across all three projects will allow us to provide consistent and reliable measurements that can be analyzed and compared across the groups. The Center for Magnetic Resonance Research (CMRR) is scientifically and technically well positioned to carry out the proposed work. The MR Core has the following goals: 1. Collect, analyze and interpret magnetic resonance spectroscopy (MRS) measurements of GABA from the three Projects. 2. Collect, analyze and interpret diffusion tensor imaging (DTI) data from the three Projects.

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National Institute on Drug Abuse (NIDA)
Exploratory Grants (P20)
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Special Emphasis Panel (ZDA1)
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University of Minnesota Twin Cities
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Chavarria-Siles, Ivan; White, Tonya; de Leeuw, Christiaan et al. (2016) Myelination-related genes are associated with decreased white matter integrity in schizophrenia. Eur J Hum Genet 24:381-6
Radke, Anna K; Zlebnik, Natalie E; Carroll, Marilyn E (2015) Cocaine withdrawal in rats selectively bred for low (LoS) versus high (HiS) saccharin intake. Pharmacol Biochem Behav 129:51-5
Holtz, Nathan A; Carroll, Marilyn E (2015) Cocaine self-administration punished by intravenous histamine in adolescent and adult rats. Behav Pharmacol 26:393-7
Camchong, Jazmin; Macdonald 3rd, Angus W; Mueller, Bryon A et al. (2014) Changes in resting functional connectivity during abstinence in stimulant use disorder: a preliminary comparison of relapsers and abstainers. Drug Alcohol Depend 139:145-51
Patzelt, Edward H; Kurth-Nelson, Zeb; Lim, Kelvin O et al. (2014) Excessive state switching underlies reversal learning deficits in cocaine users. Drug Alcohol Depend 134:211-217
Holtz, Nathan A; Anker, Justin J; Regier, Paul S et al. (2013) Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: effects of saccharin preference, impulsivity, and sex. Physiol Behav 122:32-8
Radke, Anna K; Holtz, Nathan A; Gewirtz, Jonathan C et al. (2013) Reduced emotional signs of opiate withdrawal in rats selectively bred for low (LoS) versus high (HiS) saccharin intake. Psychopharmacology (Berl) 227:117-26
Jones, Jessica A H; Lim, Kelvin O; Wozniak, Jeffrey R et al. (2013) Context-processing abilities in chronic cocaine users. Psychol Addict Behav 27:687-95
Wisner, Krista M; Atluri, Gowtham; Lim, Kelvin O et al. (2013) Neurometrics of intrinsic connectivity networks at rest using fMRI: retest reliability and cross-validation using a meta-level method. Neuroimage 76:236-51
Holtz, Nathan A; Carroll, Marilyn E (2013) Escalation of i.v. cocaine intake in peri-adolescent vs. adult rats selectively bred for high (HiS) vs. low (LoS) saccharin intake. Psychopharmacology (Berl) 227:243-50

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