Microbes evolve on a time scale that is rapid compared to the human life span. Major challenges to human health arise when evolution of drug resistance, vaccine escape, or new diseases surpass our ability to keep up through medical technology. A better understanding of the forces that cause and limit these events is required to anticipate or avoid problems caused by microbial evolution. Fundamental research done in the Center for Research on Processes in Evolution at the University of Idaho investigates the importance and consequences of critical mutagenic processes, identifies patterns of change that emerge during the course of evolution, develops and tests models to understand these patterns, and devises means to analyze large genetic data sets. Hallmarks of the Center's multidisciplinary research program are the coupling of empirical and theoretical research, a strong orientation toward rigorous testing of hypotheses, and the blending of expertise from biology, biochemistry, mathematics, statistics, and computer science to create productive interdisciplinary teams of investigators. The Center is organized and administered to address the following specific aims: (1) Conduct leading-edge multidisciplinary research in computational and evolutionary biology;(2) Broaden the base of biomedical research in evolutionary biology at the University of Idaho. (3) Mentor COBRE investigators to develop nationally competitive, independently-funded research programs;and (4) Transition to a self-sustaining Center that is independent of funding from the NIH-IDeA Program. Relevance to public health: The rapid evolution of microorganisms contributes to some of the most alarming projected crises for human health, including the emergence of new pandemics and widespread drug resistance. Traditional approaches to microbial evolution focus on the molecular details specific to particular pathogens or on theoretical models that ignore the molecular details. The Center for Research on Processes in Evolution at the University of Idaho takes a broad interdisciplinary approach that incorporates molecular details, population structure and dynamics, and an appreciation for the ecology of the human microbiome. This integrated view of microbial evolution is the next necessary step to move the field toward a more useful predictive science.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
8P20GM103397-10
Application #
8235021
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Taylor, Fred
Project Start
2002-02-23
Project End
2013-01-31
Budget Start
2012-02-01
Budget End
2013-01-31
Support Year
10
Fiscal Year
2012
Total Cost
$1,899,823
Indirect Cost
$568,675
Name
University of Idaho
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
075746271
City
Moscow
State
ID
Country
United States
Zip Code
83844
Smith, Stephanie A; Benardini 3rd, James N; Anderl, David et al. (2017) Identification and Characterization of Early Mission Phase Microorganisms Residing on the Mars Science Laboratory and Assessment of Their Potential to Survive Mars-like Conditions. Astrobiology 17:253-265
Yano, Hirokazu; Wegrzyn, Katarznya; Loftie-Eaton, Wesley et al. (2016) Evolved plasmid-host interactions reduce plasmid interference cost. Mol Microbiol 101:743-56
Loftie-Eaton, Wesley; Yano, Hirokazu; Burleigh, Stephen et al. (2016) Evolutionary Paths That Expand Plasmid Host-Range: Implications for Spread of Antibiotic Resistance. Mol Biol Evol 33:885-97
Kebaabetswe, Lemme P; Haick, Anoria K; Gritsenko, Marina A et al. (2015) Proteomic analysis reveals down-regulation of surfactant protein B in murine type II pneumocytes infected with influenza A virus. Virology 483:96-107
Garud, Nandita R; Messer, Philipp W; Buzbas, Erkan O et al. (2015) Recent selective sweeps in North American Drosophila melanogaster show signatures of soft sweeps. PLoS Genet 11:e1005004
Loftie-Eaton, Wesley; Suzuki, Haruo; Bashford, Kelsie et al. (2015) Draft Genome Sequence of Pseudomonas sp. nov. H2. Genome Announc 3:
Hether, Tyler D; Hohenlohe, Paul A (2014) Genetic regulatory network motifs constrain adaptation through curvature in the landscape of mutational (co)variance. Evolution 68:950-64
Sun, Cheng; Mueller, Rachel Lockridge (2014) Hellbender genome sequences shed light on genomic expansion at the base of crown salamanders. Genome Biol Evol 6:1818-29
Waddell, Chelsea D; Walter, Thomas J; Pacheco, Sophia A et al. (2014) NtrBC and Nac contribute to efficient Shigella flexneri intracellular replication. J Bacteriol 196:2578-86
Hunter, Samuel S; Yano, Hirokazu; Loftie-Eaton, Wesley et al. (2014) Draft Genome Sequence of Pseudomonas moraviensis R28-S. Genome Announc 2:

Showing the most recent 10 out of 20 publications