The K-INBRE network proposes to continue its Developmental Research Project Program (DRPP) to assist young investigators in garnering external funding for multidisciplinary research projects that will enhance Cell and Developmental Biology research in Kansas. The purpose of the DRPP is to support junior faculty members directing a standalone project that falls within our general theme of Cell and Developmental Biology. Each selected DRPP investigator will receive two years of support, and these projects will likely provide research opportunities for additional trainees in DRPP laboratories. A primary mentor will be identified for each awardee, and our external advisory team will develop a set of milestones specific to each project. Progress will be monitored closely by the Mentoring Core Director, in conjunction with the mentor, and funding for the second year will be contingent upon adequate progress in the first year. We anticipate awarding a total of 4 DRPP grants per year, with new applications solicited biannually or as needed when a current investigator is successful in securing external funding and ?graduates? from the program. The DRPP will provide professional oversight to maintain this long-standing and highly functional statewide program, and to expand and integrate it with existing educational and training programs operating in Kansas. The logistics of the DRPP will be successfully executed with the oversight of the Mentoring Core. Actions of the DRPP will include identifying the programmatic scope and inclusion criteria, identifying and advertising for eligible Kansas faculty, assisting in the choice of a mentor, applications submission, making funding decisions on DRPP, and carrying out evaluations and feedback of DRPP recipients. As part of the oversight of the Mentoring Core, support for this program will also be provided by the Administrative Core, Bioinformatics Core, and Communications Core. The DRPP will also provide activities and resources for DRPP awardees. Each new investigator/mentor teams to be supported by the K- INBRE will, as in the past, be carefully selected and reviewed quarterly for progress toward the goals of the research proposal and career progress. Each awardee will present his/her project in a special session before the K-INBRE Annual Symposium in January every year. The Mentoring Core will also identify and implement plans for supplementing sources of assistance for new investigators, to include information on core resources, establishing and maintaining a research laboratory, and locating research expertise available throughout the K- INBRE network. The activities and resources include establishing meetings between mentor and investigators, generating career development plans providing information on relevant seminars and meetings, identifying reserved time for research, and providing information about all available K-INBRE and COBRE core support in Kansas and the Central IDeA Region States.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103418-20
Application #
9928478
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
20
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
Xiong, Yulan; Neifert, Stewart; Karuppagounder, Senthilkumar S et al. (2018) Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice. Proc Natl Acad Sci U S A 115:1635-1640
Franklin, Meghan Whitney; Nepomnyachiy, Sergey; Feehan, Ryan et al. (2018) Efflux Pumps Represent Possible Evolutionary Convergence onto the ?-Barrel Fold. Structure 26:1266-1274.e2
Salas, Lucas A; Koestler, Devin C; Butler, Rondi A et al. (2018) An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray. Genome Biol 19:64
Hirst, Jeff; Pathak, Harsh B; Hyter, Stephen et al. (2018) Licofelone Enhances the Efficacy of Paclitaxel in Ovarian Cancer by Reversing Drug Resistance and Tumor Stem-like Properties. Cancer Res 78:4370-4385
Dahanayake, Jayangika N; Mitchell-Koch, Katie R (2018) How Does Solvation Layer Mobility Affect Protein Structural Dynamics? Front Mol Biosci 5:65
Djanaguiraman, M; Boyle, D L; Welti, R et al. (2018) Decreased photosynthetic rate under high temperature in wheat is due to lipid desaturation, oxidation, acylation, and damage of organelles. BMC Plant Biol 18:55
Gonzalez, Velda J; Abbas-Aghababazadeh, Farnoosh; Fridley, Brooke L et al. (2018) Expression of Sestrin Genes in Radiotherapy for Prostate Cancer and Its Association With Fatigue: A Proof-of-Concept Study. Biol Res Nurs 20:218-226
Velasquez, Sarah E; Abraham, K; Burnett, Tim G et al. (2018) The K-INBRE symposium: a 10-institution collaboration to improve undergraduate education. Adv Physiol Educ 42:104-110
Caton, Ingrid R; Caton, Todd M; Schneegurt, Mark A (2018) Nitrogen-fixation activity and the abundance and taxonomy of nifH genes in agricultural, pristine, and urban prairie stream sediments chronically exposed to different levels of nitrogen loading. Arch Microbiol 200:623-633
Li, Linda Xiaoyan; Zhou, Julie Xia; Calvet, James P et al. (2018) Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression. Cell Death Dis 9:326

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