The K-INBRE network proposes to continue its Developmental Research Project Program (DRPP) to assist young investigators in garnering external funding for multidisciplinary research projects that will enhance Cell and Developmental Biology research in Kansas. The purpose of the DRPP is to support junior faculty members directing a standalone project that falls within our general theme of Cell and Developmental Biology. Each selected DRPP investigator will receive two years of support, and these projects will likely provide research opportunities for additional trainees in DRPP laboratories. A primary mentor will be identified for each awardee, and our external advisory team will develop a set of milestones specific to each project. Progress will be monitored closely by the Mentoring Core Director, in conjunction with the mentor, and funding for the second year will be contingent upon adequate progress in the first year. We anticipate awarding a total of 4 DRPP grants per year, with new applications solicited biannually or as needed when a current investigator is successful in securing external funding and ?graduates? from the program. The DRPP will provide professional oversight to maintain this long-standing and highly functional statewide program, and to expand and integrate it with existing educational and training programs operating in Kansas. The logistics of the DRPP will be successfully executed with the oversight of the Mentoring Core. Actions of the DRPP will include identifying the programmatic scope and inclusion criteria, identifying and advertising for eligible Kansas faculty, assisting in the choice of a mentor, applications submission, making funding decisions on DRPP, and carrying out evaluations and feedback of DRPP recipients. As part of the oversight of the Mentoring Core, support for this program will also be provided by the Administrative Core, Bioinformatics Core, and Communications Core. The DRPP will also provide activities and resources for DRPP awardees. Each new investigator/mentor teams to be supported by the K- INBRE will, as in the past, be carefully selected and reviewed quarterly for progress toward the goals of the research proposal and career progress. Each awardee will present his/her project in a special session before the K-INBRE Annual Symposium in January every year. The Mentoring Core will also identify and implement plans for supplementing sources of assistance for new investigators, to include information on core resources, establishing and maintaining a research laboratory, and locating research expertise available throughout the K- INBRE network. The activities and resources include establishing meetings between mentor and investigators, generating career development plans providing information on relevant seminars and meetings, identifying reserved time for research, and providing information about all available K-INBRE and COBRE core support in Kansas and the Central IDeA Region States.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103418-20
Application #
9928478
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
20
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
Salas, Lucas A; Wiencke, John K; Koestler, Devin C et al. (2018) Tracing human stem cell lineage during development using DNA methylation. Genome Res 28:1285-1295
Kato, Junya; Dey, Supratim; Soto, Jose E et al. (2018) A protein secreted by the Salmonella type III secretion system controls needle filament assembly. Elife 7:
Kumar, Dhruv; New, Jacob; Vishwakarma, Vikalp et al. (2018) Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression. Cancer Res 78:3769-3782
Xiong, Yulan; Yu, Jianzhong (2018) Modeling Parkinson's Disease in Drosophila: What Have We Learned for Dominant Traits? Front Neurol 9:228
Pierce, Angela N; Eller-Smith, Olivia C; Christianson, Julie A (2018) Voluntary wheel running attenuates urinary bladder hypersensitivity and dysfunction following neonatal maternal separation in female mice. Neurourol Urodyn 37:1623-1632
Zhu, Qingfu; Heon, Mikala; Zhao, Zheng et al. (2018) Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics. Lab Chip 18:1690-1703
Ishiguro, Susumu; Kawabata, Atsushi; Zulbaran-Rojas, Alejandro et al. (2018) Co-treatment with a C1B5 peptide of protein kinase C? and a low dose of gemcitabine strongly attenuated pancreatic cancer growth in mice through T cell activation. Biochem Biophys Res Commun 495:962-968
McFarlane, Jeffrey S; Davis, Cara L; Lamb, Audrey L (2018) Staphylopine, pseudopaline, and yersinopine dehydrogenases: A structural and kinetic analysis of a new functional class of opine dehydrogenase. J Biol Chem 293:8009-8019
Ronnebaum, Trey A; McFarlane, Jeffrey S; Prisinzano, Thomas E et al. (2018) Stuffed Methyltransferase Catalyzes Penultimate Step of Pyochelin Biosynthesis. Biochemistry :
Yao, Li; Flynn, Nikol (2018) Dental pulp stem cell-derived chondrogenic cells demonstrate differential cell motility in type I and type II collagen hydrogels. Spine J 18:1070-1080

Showing the most recent 10 out of 411 publications