The mission of the Nebraska IDeA Networks of Biomedical Research Excellence (NE-INBRE) is to stimulate and develop biomedical research capacity at institutions of higher education in Nebraska. The NE-INBRE is structured around two major components: primary undergraduate institutions (PUIs) and PhD granting research institutions (RIs). Support for each PUI consists of: 1) campus research capacity development through support for faculty research and infrastructure enhancement, and 2) development of the undergraduate research pipeline of students through the NE-INBRE Scholars Program. Two features are associated with expanding research capacity at the RIs: 1) providing significant support to multi-user core facilities in order to allow investigators from PUIs and RIs access to cutting-edge technology, and 2) providing support in the form of first-year graduate assistantships for NE-INBRE scholars who matriculate into PhD programs at the RI campuses. The nine participating PUIs in the NE-INBRE research network include two publically supported State Colleges, three campuses of the University of Nebraska system, and four private institutions. The three participating RIs in the research network include two campuses of the University of Nebraska system and one privately supported medical center. Cutting edge multiuser core facilities include cores in genomics, bioinformatics, structural biology and imaging. The three themes reflect the scientific foci of the NE-INBRE, cell signaling and neuroscience, infectious disease, and structural biology and molecular biophysics. These themes serve to link faculty and students at the separate institutions into productive networks based on their areas of expertise and interest. Throughout the tenure of the NE-INBRE, its primary objective at the undergraduate level has been to provide and expand research opportunities for students and create a pipeline of students to enter into biomedical research and other health professions. NE-INBRE investments in faculty research projects and infrastructure at the PUIs have created opportunities for both NE- INBRE scholars and other undergraduate students to become involved in advanced biomedical research.

Public Health Relevance

The 'Nebraska Research Network in Functional Genomics, NE-INBRE, is designed to increase the biomedical research and training capacity at institutions of higher education and contribute to the development of the scientific workforce in the state. Primary undergraduate institutions (PUIs) receive funding to enhance their faculty research and establish modern laboratories, thus providing opportunities for undergraduate students to engage in modern research and consider entering career in research and or the health professions. Research universities receive funding to support the development of multiuser core facilities that make cutting edge technology available to research programs on these campuses.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Arora, Krishan
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Nebraska Medical Center
Schools of Medicine
United States
Zip Code
Spagnol, Gaelle; Trease, Andrew J; Zheng, Li et al. (2018) Connexin43 Carboxyl-Terminal Domain Directly Interacts with ?-Catenin. Int J Mol Sci 19:
Leiferman, Amy; Shu, Jiang; Grove, Ryan et al. (2018) A diet defined by its content of bovine milk exosomes and their RNA cargos has moderate effects on gene expression, amino acid profiles and grip strength in skeletal muscle in C57BL/6 mice. J Nutr Biochem 59:123-128
Cserhati, Matyas F; Mooter, Mary-Ellen; Peterson, Lauren et al. (2018) Motifome comparison between modern human, Neanderthal and Denisovan. BMC Genomics 19:472
Luan, Haitao; Mohapatra, Bhopal; Bielecki, Timothy A et al. (2018) Loss of the Nuclear Pool of Ubiquitin Ligase CHIP/STUB1 in Breast Cancer Unleashes the MZF1-Cathepsin Pro-oncogenic Program. Cancer Res 78:2524-2535
Desa, Danielle E; Nichols, Michael G; Smith, Heather Jensen (2018) Aminoglycosides rapidly inhibit NAD(P)H metabolism increasing reactive oxygen species and cochlear cell demise. J Biomed Opt 24:1-14
Shaw, Jeff A; Henard, Calvin A; Liu, Lin et al. (2018) Salmonella enterica serovar Typhimurium has three transketolase enzymes contributing to the pentose phosphate pathway. J Biol Chem 293:11271-11282
Kangas, Michael J; Burks, Raychelle M; Atwater, Jordyn et al. (2018) Comparative Chemometric Analysis for Classification of Acids and Bases via a Colorimetric Sensor Array. J Chemom 32:
Shute, Robert J; Heesch, Matthew W; Zak, Roksana B et al. (2018) Effects of exercise in a cold environment on transcriptional control of PGC-1?. Am J Physiol Regul Integr Comp Physiol 314:R850-R857
Won, Harim I; Schulze, Thomas T; Clement, Emalie J et al. (2018) De novo Assembly of the Burying Beetle Nicrophorus orbicollis (Coleoptera: Silphidae) Transcriptome Across Developmental Stages with Identification of Key Immune Transcripts. J Genomics 6:41-52
Baranovskiy, Andrey G; Duong, Vincent N; Babayeva, Nigar D et al. (2018) Activity and fidelity of human DNA polymerase ? depend on primer structure. J Biol Chem 293:6824-6843

Showing the most recent 10 out of 146 publications