The Proteomics Core Facility was established at the USD SSOM at the initiation of SD BRIN in 2001 to provide critical research infrastructure and capacity in South Dakota. The primary purpose of establishing a proteomics core facility (PCF) with SD BRIN support was to create, maintain and operate the facility with the capacity to support all SD researchers (faculty, postdoctoral fellows, graduate and undergraduate students) at the SD BRIN participating institutions as well as throughout the state with the capability to rapidly analyze protein expression patterns in their experimental systems.
The specific aims of the Proteomics Core are to 1) maintain the PCF (with professional staff) to be used by investigators throughout SD (and from other IDeA states ? a critical goal of the IDeA program), as well as other researchers as needed; 2) provide collaboration and research expertise as well as infrastructure to the participating institutions in the control of cell growth with special emphasis on proteomics; and 3) improve and develop protocols to assist the future plans of researchers from participating institutions and develop collaborations among SD biomedical researchers. The impact of the Proteomics core has already been seen and is exemplified by the more than 100 faculty and graduate student projects that have received PCF support since its inception. These projects have resulted in 33 research publications and 31 presentations that have advanced knowledge in areas relevant to public health such as disease treatment and prevention through the elucidation of the structures of bioactive compounds. Action steps to accomplish the specific aims of the Proteomics Core include the provision of funding to support the core director, maintain the equipment, and provide reagents necessary to run the instrumentation, and a focused effort on the identification of faculty research needs through a needs assessment. The expected outcomes are increased collaborative research, and enhanced resources and capacity to support biomedical research which in turn will lead to an increase in the number of successful grant proposals, publications and presentations that include a proteomics component. Maintenance of the Proteomics Core will continue to have a positive impact on the program goals of SD BRIN as the biomedical research capacity of South Dakota continues to grow.

Public Health Relevance

Proteomics Core Narrative The Proteomics Core Facility was established at the initiation of SD BRIN in 2001 to provide critical research infrastructure and capacity that was not available in South Dakota. The PCF director has consulted with more than 100 researchers in helping them to define and implement their protein expression research needs. In addition, the PCF director has developed several new protocols and additional analyses needed by SD biomedical researchers.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103443-14A1
Application #
8897715
Study Section
Special Emphasis Panel (ZGM1-TWD-0 (IN))
Project Start
Project End
Budget Start
2015-07-15
Budget End
2016-04-30
Support Year
14
Fiscal Year
2015
Total Cost
$293,049
Indirect Cost
$59,996
Name
University of South Dakota
Department
Type
DUNS #
929930808
City
Vermillion
State
SD
Country
United States
Zip Code
57069
Bosch, T J; Hanna, T; Fercho, K A et al. (2018) Behavioral performance and visual strategies during skill acquisition using a novel tool use motor learning task. Sci Rep 8:13755
Anderson, Ruthellen H; Lensing, Cody J; Forred, Benjamin J et al. (2018) Differentiating Antiproliferative and Chemopreventive Modes of Activity for Electron-Deficient Aryl Isothiocyanates against Human MCF-7 Cells. ChemMedChem 13:1695-1710
Klonoski, Joshua M; Watson, Trevor; Bickett, Thomas E et al. (2018) Contributions of Influenza Virus Hemagglutinin and Host Immune Responses Toward the Severity of Influenza Virus: Streptococcus pyogenes Superinfections. Viral Immunol 31:457-469
Dosch, John; Hadley, Elise; Wiese, Cal et al. (2018) Time-lapse microscopic observation of non-dividing cells in cultured human osteosarcoma MG-63 cell line. Cell Cycle 17:174-181
Liang, Ashley Paula; Drazick, Anthony Thomas; Gao, Hongbo et al. (2018) Skeletal muscle secretion of IL-6 is muscle type specific: Ex vivo evidence. Biochem Biophys Res Commun 505:146-150
Herrera, Andrea L; Faal, Haddy; Moss, Danielle et al. (2018) The Streptococcus pyogenes fibronectin/tenascin-binding protein PrtF.2 contributes to virulence in an influenza superinfection. Sci Rep 8:12126
Adili, Reheman; Voigt, Ellen M; Bormann, Jordan L et al. (2017) In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi. Platelets :1-9
Dachineni, Rakesh; Kumar, D Ramesh; Callegari, Eduardo et al. (2017) Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer. Int J Oncol 51:1661-1673
Grausam, Katie B; Dooyema, Samuel D R; Bihannic, Laure et al. (2017) ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas. Cancer Res 77:3766-3777
Madison, Joseph D; Berg, Elizabeth A; Abarca, Juan G et al. (2017) Characterization ofBatrachochytrium dendrobatidisInhibiting Bacteria from Amphibian Populations in Costa Rica. Front Microbiol 8:290

Showing the most recent 10 out of 64 publications