South Dakota Biomedical Research Infrastructure Network (SD BRIN), hosted by the Sanford School of Medicine of the University of South Dakota (USD) in Vermillion, SD, is the SD component of IDeA Networks of Biomedical Research Excellence (INBRE) funded by the NIH/NIGMS Institutional Development Award (IDeA) program since 2002. This proposal has evolved from insights gained and enhancements made during the previous phase of INBRE (2015-2020) especially related to the successful implementation of the Developmental Research Project Program for advancing the research initiatives of participating faculty members from our partners at predominantly undergraduate institutions.
The specific aims of the SD BRIN program have not changed from its beginning. SD BRIN Aim 1 addresses the needs of biomedical researchers at USD (the lead research intensive institution) and provides resources and support to other researchers throughout the state. SD BRIN Aim 2 addresses the needs of science faculty and undergraduate researchers at the partner predominantly undergraduate institutions and tribal colleges. Therefore, the aims of this phase of INBRE in South Dakota are to: 1) Continue to develop the research capacity of South Dakota in the area of cell biology and the control of cell growth with special emphasis on proteomics and genomics by: a) enhancing the research capacity of investigators in proteomics, b) maintaining proteomics, bioinformatics, and nucleic acid sequencing and genotyping core facilities (with professional staff) accessible to investigators throughout SD (and other IDeA states), c) offering opportunities for graduate training in proteomics, nucleic acid sequencing, and bioinformatics, and d) supporting access to online library scientific databases to all faculty and students from all SD BRIN participating institutions. 2) Develop human resources for undergraduate and graduate programs in the biomedical sciences and bioinformatics by helping to instill a culture of research and provide a pipeline for students interested in biomedical research at South Dakota?s predominantly undergraduate institutions and tribal colleges by: a) providing research support and mentoring for faculty from participating institutions, b) providing opportunities for, and understanding of, cutting-edge scientific research for students at participating institutions, c) introducing undergraduates to graduate programs and future careers in biomedical sciences and bioinformatics, and d) enhancing science education and research capabilities at tribal colleges, providing opportunities for further education and careers in science and research.

Public Health Relevance

SD BRIN has supported a robust network of faculty researchers throughout South Dakota in developing and maintaining new areas of biomedical research by providing expert resources in core facilities available to all researchers. In addition, SD BRIN has maintained a strong undergraduate research fellows program at predominantly undergraduate institutions (PUI) with growing research cultures to develop future biomedical researchers and to assist faculty mentors with their cutting-edge research efforts. The faculty fellows program has allowed PUI faculty to concentrate on their research efforts and use this support to increase publications and application to external funding agencies.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM103443-19
Application #
9900308
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Zhou, Yang
Project Start
2001-09-24
Project End
2025-08-31
Budget Start
2020-09-10
Budget End
2021-08-31
Support Year
19
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of South Dakota
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
929930808
City
Vermillion
State
SD
Country
United States
Zip Code
57069
Bosch, T J; Hanna, T; Fercho, K A et al. (2018) Behavioral performance and visual strategies during skill acquisition using a novel tool use motor learning task. Sci Rep 8:13755
Anderson, Ruthellen H; Lensing, Cody J; Forred, Benjamin J et al. (2018) Differentiating Antiproliferative and Chemopreventive Modes of Activity for Electron-Deficient Aryl Isothiocyanates against Human MCF-7 Cells. ChemMedChem 13:1695-1710
Klonoski, Joshua M; Watson, Trevor; Bickett, Thomas E et al. (2018) Contributions of Influenza Virus Hemagglutinin and Host Immune Responses Toward the Severity of Influenza Virus: Streptococcus pyogenes Superinfections. Viral Immunol 31:457-469
Dosch, John; Hadley, Elise; Wiese, Cal et al. (2018) Time-lapse microscopic observation of non-dividing cells in cultured human osteosarcoma MG-63 cell line. Cell Cycle 17:174-181
Liang, Ashley Paula; Drazick, Anthony Thomas; Gao, Hongbo et al. (2018) Skeletal muscle secretion of IL-6 is muscle type specific: Ex vivo evidence. Biochem Biophys Res Commun 505:146-150
Herrera, Andrea L; Faal, Haddy; Moss, Danielle et al. (2018) The Streptococcus pyogenes fibronectin/tenascin-binding protein PrtF.2 contributes to virulence in an influenza superinfection. Sci Rep 8:12126
Messerli, Shanta M; Hoffman, Mariah M; Gnimpieba, Etienne Z et al. (2017) Therapeutic Targeting of PTK7 is Cytotoxic in Atypical Teratoid Rhabdoid Tumors. Mol Cancer Res 15:973-983
Messerli, Shanta M; Hoffman, Mariah M; Gnimpieba, Etienne Z et al. (2017) 4SC-202 as a Potential Treatment for the Pediatric Brain Tumor Medulloblastoma. Brain Sci 7:
Wegehaupt, Abby K; Roufs, Ellen K; Hewitt, Cory R et al. (2017) Recovery and assessment of leukocytes from LR Express filters. Biologicals 49:15-22
Oleas, Gabriela; Callegari, Eduardo; Sepúlveda, Romina et al. (2017) Heterologous expression, purification and characterization of three novel esterases secreted by the lignocellulolytic fungus Penicillium purpurogenum when grown on sugar beet pulp. Carbohydr Res 443-444:42-48

Showing the most recent 10 out of 64 publications