- Administrative and Mentoring Core In Phase I of the Institute for Biogenesis Research (IBR) COBRE, the Administrative Core was able to develop unique and effective administrative strategies in order to coordinate the day-to-day management of the center grant, which accommodates faculty and staff on two separate campuses. Our administrative staff were themselves united into one facility, which enhanced the effectiveness of their daily interactions and allowed them to become a much more efficient management team. Additionally, the Administrative Core successfully designed and enacted a mentoring strategy that evolved with the intensive participation of the External Advisory Committee (EAC), which remains highly dedicated to the development of the IBR as demonstrated by their continued participation in Phase II. In this Phase II application, we have applied this experience to the design of our current strategies for administering the IBR COBRE and to use the resources it provides to maximally enhance the development of the institution and the IBR's research capacity. The overall goal of this core is the same as that of the application as a whole, which is to strengthen and transform the IBR into a multi-disciplinary reproductive biology research center that will become independent enough to be sustained on extramural grant support for its future development. The particular emphasis of the Administrative Core is the coordination of all the resources to mentor the four Project Leaders and to support the transformation of the IBR into a multi-faceted center that includes a strong component of translational and clinical research. This will be accomplished through the following specific aims: (SA1) Enhance the Administrative Core to effectively coordinate and manage the mentoring of the four Project Leaders of Phase II and to promote the continued development of the Project Leaders of Phase I and the IBR. The Administrative Core will be directed by Dr. W. Steven Ward, the IBR COBRE PI. He will also be advised by two other experienced COBRE PIs at UH and the External Advisory Committee. (SA2) Develop individual mentoring plans for each of the four Project Leaders. The Administrative Core with the help of the EAC has developed a detailed mentoring plan the four Project Leaders that is specific for the unique challenge of mentoring junior faculty our remote location. (SA3) Enhance the interactions between all IBR faculty to develop collaborative projects. The major theme of the IBR COBRE Phase II is to enhance and transform the IBR into an institute that will be self sustaining. An important component of scientific success is through collaborations. The Administrative Core will foster the development of collaborative reproductive biology research projects between IBR investigators with each other and with external scientists who interact with the IBR through the Yanagimachi Lecture Series, as mentors, or as External Advisory Committee members. Finally, the Administrative Core will support pilot projects in reproductive biology research to identify new faculty at the University of Hawaii to collaborate on reproductive biology research with the intent of further diversifying the research expertise of the Center.

Public Health Relevance

- Administrative and Mentoring Core The major role of the Administrative Core is to coordinate the mentoring of the four junior faculty that are supported in this application. The Core has developed a unique method for mentoring faculty in the remote location of Hawaii using the COBRE resources to develop interactions between Hawaii scientists and nationally prominent mentors.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
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Special Emphasis Panel (ZGM1)
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University of Hawaii
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Polgar, Noemi; Fogelgren, Ben (2018) Regulation of Cell Polarity by Exocyst-Mediated Trafficking. Cold Spring Harb Perspect Biol 10:
O'Brien, Lori L; Guo, Qiuyu; Bahrami-Samani, Emad et al. (2018) Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies. PLoS Genet 14:e1007181
Poirion, Olivier; Zhu, Xun; Ching, Travers et al. (2018) Using single nucleotide variations in single-cell RNA-seq to identify subpopulations and genotype-phenotype linkage. Nat Commun 9:4892
Alakwaa, Fadhl M; Chaudhary, Kumardeep; Garmire, Lana X (2018) Deep Learning Accurately Predicts Estrogen Receptor Status in Breast Cancer Metabolomics Data. J Proteome Res 17:337-347
Chaudhary, Kumardeep; Poirion, Olivier B; Lu, Liangqun et al. (2018) Deep Learning-Based Multi-Omics Integration Robustly Predicts Survival in Liver Cancer. Clin Cancer Res 24:1248-1259
Poirion, Olivier B; Chaudhary, Kumardeep; Garmire, Lana X (2018) Deep Learning data integration for better risk stratification models of bladder cancer. AMIA Jt Summits Transl Sci Proc 2017:197-206
Alarcon, Vernadeth B; Marikawa, Yusuke (2018) ROCK and RHO Playlist for Preimplantation Development: Streaming to HIPPO Pathway and Apicobasal Polarity in the First Cell Differentiation. Adv Anat Embryol Cell Biol 229:47-68
Ching, Travers; Garmire, Lana X (2018) Pan-cancer analysis of expressed somatic nucleotide variants in long intergenic non-coding RNA. Pac Symp Biocomput 23:512-523
Lee, Ryan W Y; Corley, Michael J; Pang, Alina et al. (2018) A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder. Physiol Behav 188:205-211
Kim, Iris Q; Marikawa, Yusuke (2018) Embryoid body test with morphological and molecular endpoints implicates potential developmental toxicity of trans-resveratrol. Toxicol Appl Pharmacol 355:211-225

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