The multidisciplinary Nebraska Center for Nanomedicine (NCN), established in 2008 with Center for Biomedical Research Excellence (COBRE) funding, is building a nationally and internationally recognized program of excellence in nanomedicine that combines broad expertise in material, pharmaceutical and biological sciences driven by innovative research. NCN has completed its original objectives and enhanced Nebraska's biomedical research capacity by creating a strategically linked infrastructure of strong collaborative research programs and by mentoring a cadre of talented junior faculty to independent success. 26 NCN members (all COBRE key personnel) have a total of 292 publications (including 86 by mentored junior faculty), 99 new patent applications along with 46 grants (16 related to nanomedicine). This NCN COBRE continuation proposal details our plan to continue building and to sustain a biomedical research center of national prominence and international recognition.
The specific aims that move the NCN toward these goals over the next five years are: 1) continue to expand existing research strengths through the support of five thematically linked projects and mentorship of junior faculty into independent investigators;2) grow research capacity through the pilot project program and the support of innovative projects by experienced researchers with a focus on expanding translational capabilities and clinical research collaborations;3) continue targeted faculty recruitment to broaden the scope and expertise in the area of nanomedicine research;and 4) sustain the support of essential scientific core facilities, which serve as platforms to increase the capacity f NCN members to compete successfully for NIH funding. The realization of these aims will allow the NCN to emerge from Phase II funding as self-sustaining center of research excellence in nanomedicine, with an increased capacity to pursue programmatic support through individual and multi-investigator, program-wide research grants. Through the development and clinical translation of effective nanomedicines for diagnosis and therapy for human diseases, the NCN will ultimately provide significant benefits for the health of Nebraskans and society at large.
Research and development of biomedical methodologies based on nanomaterials, addresses urgent needs for effectively detecting diseases and improving therapy through the delivery of drugs, therapeutic proteins and genes to the focal areas of disease or to tumors, which will maximize clinical benefit while limiting untoward side effects.
|Jiang, Jiang; Zhang, Yang; Indra, Arup K et al. (2018) 1?,25-dihydroxyvitamin D3-eluting nanofibrous dressings induce endogenous antimicrobial peptide expression. Nanomedicine (Lond) 13:1417-1432|
|Qi, Bowen; Crawford, Ayrianne J; Wojtynek, Nicholas E et al. (2018) Indocyanine green loaded hyaluronan-derived nanoparticles for fluorescence-enhanced surgical imaging of pancreatic cancer. Nanomedicine 14:769-780|
|Weng, Lin; Boda, Sunil Kumar; Wang, Hongjun et al. (2018) Novel 3D Hybrid Nanofiber Aerogels Coupled with BMP-2 Peptides for Cranial Bone Regeneration. Adv Healthc Mater 7:e1701415|
|Jiang, Jiang; Chen, Shixuan; Wang, Hongjun et al. (2018) CO2-expanded nanofiber scaffolds maintain activity of encapsulated bioactive materials and promote cellular infiltration and positive host response. Acta Biomater 68:237-248|
|Ambardekar, Vishakha V; Wakaskar, Rajesh R; Ye, Zhen et al. (2018) Complexation of Chol-DsiRNA in place of Chol-siRNA greatly increases the duration of mRNA suppression by polyplexes of PLL(30)-PEG(5K) in primary murine syngeneic breast tumors after i.v. administration. Int J Pharm 543:130-138|
|Wehrkamp, Cody J; Natarajan, Sathish Kumar; Mohr, Ashley M et al. (2018) miR-106b-responsive gene landscape identifies regulation of Kruppel-like factor family. RNA Biol 15:391-403|
|Souchek, Joshua J; Wojtynek, Nicholas E; Payne, William M et al. (2018) Hyaluronic acid formulation of near infrared fluorophores optimizes surgical imaging in a prostate tumor xenograft. Acta Biomater 75:323-333|
|Payne, William M; Svechkarev, Denis; Kyrychenko, Alexander et al. (2018) The role of hydrophobic modification on hyaluronic acid dynamics and self-assembly. Carbohydr Polym 182:132-141|
|Svechkarev, Denis; Kyrychenko, Alexander; Payne, William M et al. (2018) Probing the self-assembly dynamics and internal structure of amphiphilic hyaluronic acid conjugates by fluorescence spectroscopy and molecular dynamics simulations. Soft Matter 14:4762-4771|
|Chatterjee, Arpita; Zhu, Yuxiang; Tong, Qiang et al. (2018) The Addition of Manganese Porphyrins during Radiation Inhibits Prostate Cancer Growth and Simultaneously Protects Normal Prostate Tissue from Radiation Damage. Antioxidants (Basel) 7:|
Showing the most recent 10 out of 90 publications