Overarching goal of the Center is to understand the mechanisms of pathophysiology of diabetes and obesity and their cardiovascular complications. The Pathology and Bio-analytics Core is an integral part ofthe Center and will play a key role in the evolution of COBRE-funded projects. The Core will render services for rigorous and comprehensive pathological analysis of diabetic specimens. It will provide intellectual input with experimental design and state-of-the-art technical expertise to address the needs of investigators. The Core consists of a group of outstanding scientists with expertise in cardiovascular physiology, pathology and analytical biochemistry. Director ofthe Core, Dr. Sanjay Srivastava more than twenty years of research experience in analytical biochemistry and pathology, and vascular inflammation, atherosclerosis and diabetes. He will oversee all the Core operations and will work closely with junior investigators to teach them principles of histology, chromatography and mass spectrometry. Dr Srivastava will also help the COBRE investigators with quantification and characterization of atherosclerotic lesions. Dr. Michael Merchant, coinvestigator in the Core has extensive experience in analytical biochemistry and will assist the COBRE investigators with proteomics analyses. Drs. Srivastava and Merchant will provide hands on training to junior investigators for various histology and bio-analytical assays. The training acquired at the Core will facilitate them to grow as scientists and expand their repertoire of technical skills. The Core is equipped with state-ofthe- art pathology and analytical biochemistry equipment and is located in the Delia Baxter Building. In addition to address the current requirements of the COBRE projects, the Core will continue to expand its knowledgebase and technical expertise to satisfy the future needs of the Center. Long term goal of the Core is to become a fiscally independent entity capable of providing cutting-edge pathology and bio-analytical services to researchers interested in diabetes and cardiovascular pathophysiology. Continued excellence in pathological analyses will foster collaborations which will not only help the Core financially, but will also advance the field in combatting diabetic complications.

Public Health Relevance

The Pathology and Bio-analytics Core of the Center will provide technical expertise in the pathological examination and quantification of various analytes in diabetic tissues. The Core will train junior investigators with histological assessment and biochemical analyses of diabetic tissues and tease out the biochemical mechanisms associated with the onset of diabetes and obesity and their cardiovascular complications.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103492-07
Application #
8711507
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
7
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Louisville
Department
Type
DUNS #
City
Louisville
State
KY
Country
United States
Zip Code
40202
Lindsey, Merry L; Bolli, Roberto; Canty Jr, John M et al. (2018) Guidelines for experimental models of myocardial ischemia and infarction. Am J Physiol Heart Circ Physiol 314:H812-H838
Uchida, Shizuka; Jones, Steven P (2018) RNA Editing: Unexplored Opportunities in the Cardiovascular System. Circ Res 122:399-401
Liang, Yaqin; Lang, Anna L; Zhang, Jian et al. (2018) Exposure to Vinyl Chloride and Its Influence on Western Diet-Induced Cardiac Remodeling. Chem Res Toxicol 31:482-493
Trainor, Patrick J; Yampolskiy, Roman V; DeFilippis, Andrew P (2018) Wisdom of artificial crowds feature selection in untargeted metabolomics: An application to the development of a blood-based diagnostic test for thrombotic myocardial infarction. J Biomed Inform 81:53-60
Zafar, Nagma; Krishnasamy, Sathya S; Shah, Jasmit et al. (2018) Circulating angiogenic stem cells in type 2 diabetes are associated with glycemic control and endothelial dysfunction. PLoS One 13:e0205851
Hoetker, David; Chung, Weiliang; Zhang, Deqing et al. (2018) Exercise alters and ?-alanine combined with exercise augments histidyl dipeptide levels and scavenges lipid peroxidation products in human skeletal muscle. J Appl Physiol (1985) :
Baba, Shahid P; Bhatnagar, Aruni (2018) ROLE OF THIOLS IN OXIDATIVE STRESS. Curr Opin Toxicol 7:133-139
Abplanalp, Wesley; Wickramasinghe, Nalinie S; Sithu, Srinivas D et al. (2018) Benzene exposure induces insulin resistance in mice. Toxicol Sci :
Nystoriak, Matthew A; Bhatnagar, Aruni (2018) Cardiovascular Effects and Benefits of Exercise. Front Cardiovasc Med 5:135
Nystoriak, Matthew A; Navedo, Manuel F (2018) Regulation of microvascular function by voltage-gated potassium channels: New tricks for an ""ancient"" dog. Microcirculation 25:

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