Abstract

The Physiologic Core (C) will be located in the Division of Animal Laboratory Resources within dedicated space at the University of Kentucky. This core will provide equipment, services and training for quantifying cardiovascular, diabetes, and obesity phenotypes. This includes measurement of atherosclerosis, quantifying sera lipoprotein cholesterol, ultrasound for assessing vascular and cardiac function, MRI for analyzing cardiac function and fat deposifion, and tail cuff and radiotelemetry platforms to quantify blood pressure. For diabetes, this includes training and service in performing glucose and insulin tolerance tests in mice, and for small scale studies using euglycemic hyperinsulinemic clamps in mice. For obesity, this includes echoMRI to quantify fat/lean mass, TSE LabMaster chambers to quantify food/water intake, physical activity and indirect calorimetry, and PhenoMaster chambers for urine/feces collection.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
4P20GM103527-09
Application #
9135487
Study Section
Special Emphasis Panel (ZGM1-TWD-Y)
Project Start
Project End
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
9
Fiscal Year
2016
Total Cost
$188,700
Indirect Cost
$63,318

  Institution

Name
University of Kentucky
Department
Type
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506

  Publications

Thompson, Joel C; Wilson, Patricia G; Wyllie, Alex P et al. (2018) Elevated circulating TGF-? is not the cause of increased atherosclerosis development in biglycan deficient mice. Atherosclerosis 268:68-75
Thalman, Carine; Horta, Guilherme; Qiao, Lianyong et al. (2018) Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders. Mol Psychiatry 23:1699-1710
Lee, Scott J; Zea, Ryan; Kim, David H et al. (2018) CT texture features of liver parenchyma for predicting development of metastatic disease and overall survival in patients with colorectal cancer. Eur Radiol 28:1520-1528
Brandon, Jason A; Farmer, Brandon C; Williams, Holden C et al. (2018) APOE and Alzheimer's Disease: Neuroimaging of Metabolic and Cerebrovascular Dysfunction. Front Aging Neurosci 10:180
Sui, Yipeng; Park, Se-Hyung; Wang, Fang et al. (2018) Perinatal Bisphenol A Exposure Increases Atherosclerosis in Adult Male PXR-Humanized Mice. Endocrinology 159:1595-1608
Sui, Yipeng; Liu, Zun; Park, Se-Hyung et al. (2018) IKK? is a ?-catenin kinase that regulates mesenchymal stem cell differentiation. JCI Insight 3:
Deng, Pan; Barney, Jazmyne; Petriello, Michael C et al. (2018) Hepatic metabolomics reveals that liver injury increases PCB 126-induced oxidative stress and metabolic dysfunction. Chemosphere 217:140-149
Al-Darraji, Ahmed; Haydar, Dalia; Chelvarajan, Lakshman et al. (2018) Azithromycin therapy reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction: Potential therapeutic targets in ischemic heart disease. PLoS One 13:e0200474
Zaytseva, Yekaterina Y; Rychahou, Piotr G; Le, Anh-Thu et al. (2018) Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. Oncotarget 9:24787-24800
Meier, Shelby; Gilad, Assaf A; Brandon, J Anthony et al. (2018) Non-invasive detection of adeno-associated viral gene transfer using a genetically encoded CEST-MRI reporter gene in the murine heart. Sci Rep 8:4638

Showing the most recent 10 out of 235 publications