The Center of Biomedical Research Excellence in Biomolecular Structure and Dynamics at the University of Montana (CBSD COBRE) supports research that applies the methods and concepts of biophysics, structural biology and chemistry to understand the mechanistic basis of biological processes in health and disease. CBSD faculty members are drawn from the basic and biomedical sciences in the Colleges of Humanities and Sciences and the College of Health Professions and Biomedical Sciences. Disciplines represented by Center faculty include cellular biology, pharmacology, neurobiology, biochemistry, synthetic chemistry and computational research in chemistry and biology.
The first aim of the Phase II CBSD COBRE program is to support and mentor CBSD Investigators by: a) supporting four Junior Project Investigators who will conduct research in the general theme of small molecules that regulate or mimic protein receptors and enzymes; b) conducting an effective and robust mentoring program to guide Junior Investigators along the path towards academic success and independent funding; c) identifying and supporting strong replacement projects within the CBSD research theme, inviting both established investigators and collaborative projects to strengthen the research cohesion of the Center; and d) maintaining a Pilot Project and Bridge-funding Program to encourage innovative explorative research and sustain productive Investigators while they pursue independent funding.
Aim 2 of the proposal is to carry on the work of Phase I to build a strong cohort of CBSD investigators though strategic faculty recruitment, supported by Career Development Awards, emphasizing the structure and dynamics of macromolecular assemblies in biological processes.
Aim 3 advances the Core Facility structure of the CBSD by: a) maintaining a strong Administrative Core that provides effective leadership, oversight and financial management of the Center; b) developing additional capability in the Macromolecular X-ray Diffraction Core Facility to conduct protein expression and purification, as well as small molecule X-ray crystallography; c) developing advanced capabilities in the BioSpectroscopy Core Research Laboratory in time-resolved fluorescence spectroscopy, including single molecule analysis, and d) consolidating an integrated collaborative facility for protein modeling and molecular and dynamics in the Molecular Computation Core Facility.
Aim 4 of the application is to conduct an array of programmatic activities to promote program cohesion and scientific excellence. An important overall goal of this proposal is to foster a self-sustainable Center by mentoring and supporting a community of outstanding junior and established investigators, and by adopting multiple funding streams to ensure sustainable Core Research Facilities.

Public Health Relevance

Overall Component: Project Narrative The Center of Biomolecular Structure and Dynamics, an NIH Center of Biomedical Research Excellence, supports research programs that facilitate the use of biophysical and molecular structural approaches discover new avenues to understand normal and pathological physiological processes. This proposal supports Junior Investigators who are conducting research programs that will lay the groundwork to discover new therapies for diabetes, chronic lung inflammatory disease, and neurodegenerative disease, and that will lay the foundation for new catalytic methods to synthesize pharmaceuticals.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
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Special Emphasis Panel (ZGM1)
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Caldwell, Sheila
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University of Montana
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United States
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Beamer, Celine A; Kreitinger, Joanna M; Cole, Shelby L et al. (2018) Targeted deletion of the aryl hydrocarbon receptor in dendritic cells prevents thymic atrophy in response to dioxin. Arch Toxicol :
Bhattacharya, Subhrajit; Khatri, Alpa; Swanger, Sharon A et al. (2018) Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells. Neuron 99:315-328.e5
Riel, Asia Marie S; Decato, Daniel A; Sun, Jiyu et al. (2018) The intramolecular hydrogen bonded-halogen bond: a new strategy for preorganization and enhanced binding. Chem Sci 9:5828-5836
Stump, Sascha; Mou, Tung-Chung; Sprang, Stephen R et al. (2018) Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene. PLoS One 13:e0205584
Secor, Patrick R; Michaels, Lia A; Ratjen, Anina et al. (2018) Entropically driven aggregation of bacteria by host polymers promotes antibiotic tolerance in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 115:10780-10785
Hansen, Kasper B; Yi, Feng; Perszyk, Riley E et al. (2018) Structure, function, and allosteric modulation of NMDA receptors. J Gen Physiol 150:1081-1105
Brust, Richard; Shang, Jinsai; Fuhrmann, Jakob et al. (2018) A structural mechanism for directing corepressor-selective inverse agonism of PPAR?. Nat Commun 9:4687
Day, Nicholas J; Ellenbecker, Mary; Voronina, Ekaterina (2018) Caenorhabditis elegans DLC-1 associates with ribonucleoprotein complexes to promote mRNA regulation. FEBS Lett 592:3683-3695
Gates, Christina; Backos, Donald S; Reigan, Philip et al. (2018) Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4. Bioorg Med Chem 26:4797-4803
Tait Wojno, Elia D; Beamer, Celine A (2018) Isolation and Identification of Innate Lymphoid Cells (ILCs) for Immunotoxicity Testing. Methods Mol Biol 1803:353-370

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