Abstract

BioSpectroscopy Core Research Laboratory (BCRL) Project Summary The BioSpectroscopy Core Research Laboratory (BCRL) supports the research activities of CBSD investigators, integrating its research activities with other CBSD core research facilities (computational, X-ray diffraction), to provide a synergistic and multi-disciplinary approach to address fundamental questions in biophysics, biochemistry, molecular biology and biomedical sciences. The mission of the BCRL is to facilitate the research programs of CBSD investigators and their trainees, and other UM investigators and their trainees, by serving as a collaborative research resource for state-of-the-art time-resolved fluorescence spectroscopy and imaging, as well as single-molecule spectroscopy. The BCRL accomplishes its mission by providing investigators, and their trainees, access to high-end spectroscopy instrumentation, technologies, services, and consultation; by dissemination; and by providing educational training opportunities for graduate students interested in broadening their knowledge of fluorescence theory and techniques in biophysical applications.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103546-10
Application #
10004082
Study Section
Special Emphasis Panel (ZGM1)
Project Start
2011-09-01
Project End
2021-07-31
Budget Start
2020-08-01
Budget End
2021-07-31
Support Year
10
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of Montana
Department
Type
DUNS #
010379790
City
Missoula
State
MT
Country
United States
Zip Code
59812

  Publications

Beamer, Celine A; Kreitinger, Joanna M; Cole, Shelby L et al. (2018) Targeted deletion of the aryl hydrocarbon receptor in dendritic cells prevents thymic atrophy in response to dioxin. Arch Toxicol :
Bhattacharya, Subhrajit; Khatri, Alpa; Swanger, Sharon A et al. (2018) Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule Cells. Neuron 99:315-328.e5
Riel, Asia Marie S; Decato, Daniel A; Sun, Jiyu et al. (2018) The intramolecular hydrogen bonded-halogen bond: a new strategy for preorganization and enhanced binding. Chem Sci 9:5828-5836
Stump, Sascha; Mou, Tung-Chung; Sprang, Stephen R et al. (2018) Crystal structure of the major quadruplex formed in the promoter region of the human c-MYC oncogene. PLoS One 13:e0205584
Secor, Patrick R; Michaels, Lia A; Ratjen, Anina et al. (2018) Entropically driven aggregation of bacteria by host polymers promotes antibiotic tolerance in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 115:10780-10785
Hansen, Kasper B; Yi, Feng; Perszyk, Riley E et al. (2018) Structure, function, and allosteric modulation of NMDA receptors. J Gen Physiol 150:1081-1105
Brust, Richard; Shang, Jinsai; Fuhrmann, Jakob et al. (2018) A structural mechanism for directing corepressor-selective inverse agonism of PPAR?. Nat Commun 9:4687
Day, Nicholas J; Ellenbecker, Mary; Voronina, Ekaterina (2018) Caenorhabditis elegans DLC-1 associates with ribonucleoprotein complexes to promote mRNA regulation. FEBS Lett 592:3683-3695
Gates, Christina; Backos, Donald S; Reigan, Philip et al. (2018) Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4. Bioorg Med Chem 26:4797-4803
Tait Wojno, Elia D; Beamer, Celine A (2018) Isolation and Identification of Innate Lymphoid Cells (ILCs) for Immunotoxicity Testing. Methods Mol Biol 1803:353-370

Showing the most recent 10 out of 108 publications