The Administrative and Scientific Development Core (Core A) will provide administrative, fiscal, and scientific support for the proposed Center for Microbial Pathogenesis and Host Inflammatory Responses by operating and maintaining a COBRE Center (Aim 1), fostering scientific growth through mentoring and faculty development (Aim 2), and fostering growth and expansion of the COBRE Center and its programs (Aim 3). The Center's goal is to address infectious disease in a therapeutically relevant fashion by understanding both the microbial virulence factors that contribute to the disease process and how these factors impact the host immunological and inflammatory response to determine the ultimate clinical outcome. The Administrative and Scientific Development Core will rely on Internal and External Advisory Committees, experienced mentors, and a seasoned administrative team operating under the leadership of the Center Director to guide four Project Leaders who focus on the Center's theme to independent external funding. The Core's leadership team will also develop a """"""""pipeline"""""""" of potential Project Leaders, junior investigators and experienced scientists who are interested in becoming active in research regarding microbial pathogens and host response and will continue to support Project Leaders who have """"""""graduated"""""""" to external funding at the ROI level. This Core will also train new mentors, initiate a Distinguished Lecturer Series to attract new scientists to the field, provide pilot funding to encourage new research, and evaluate the Center and its projects. Successful operation of this Core will enable the Center to achieve the following milestones within 5 years of funding: 3 independently funded new PIs associated with the Center, 2-4 new mentors, 3-5 potential new Project Leaders, 8-15 publications in peer-reviewed journals, and 1 program project grant in the early stages of planning.
of this Core relates to its role in supporting a Center that will address the persistent problem of infectious disease, specifically the role of pathogens and their impact on the body's immunological and inflammatory response. This Core will provide administrative, fiscal, and scientific support for scientists who will investigate complex interactions between microbial pathogens and their human hosts from the perspectives of both the pathogen itself and the host response. Their work has the potential to significantly enhance the ability to control the devastating consequences of many infectious diseases, including those caused by pathogens that are resistant to antibiotics.
|Diaz, Paola Monterroso; Jenkins, Samir V; Alhallak, Kinan et al. (2018) Quantitative diffuse reflectance spectroscopy of short-term changes in tumor oxygenation after radiation in a matched model of radiation resistance. Biomed Opt Express 9:3794-3804|
|Wikenheiser, Daniel J; Brown, Susie L; Lee, Juhyung et al. (2018) NK1.1 Expression Defines a Population of CD4+ Effector T Cells Displaying Th1 and Tfh Cell Properties That Support Early Antibody Production During Plasmodium yoelii Infection. Front Immunol 9:2277|
|Esteves, Pedro J; Abrantes, Joana; Baldauf, Hanna-Mari et al. (2018) The wide utility of rabbits as models of human diseases. Exp Mol Med 50:66|
|Stuart, Johnasha D; Holm, Geoffrey H; Boehme, Karl W (2018) Differential Delivery of Genomic Double-Stranded RNA Causes Reovirus Strain-Specific Differences in Interferon Regulatory Factor 3 Activation. J Virol 92:|
|Meeker, Daniel G; Wang, Tengjiao; Harrington, Walter N et al. (2018) Versatility of targeted antibiotic-loaded gold nanoconstructs for the treatment of biofilm-associated bacterial infections. Int J Hyperthermia 34:209-219|
|Jenkins, Samir V; Nedosekin, Dmitry A; Miller, Emily K et al. (2018) Galectin-1-based tumour-targeting for gold nanostructure-mediated photothermal therapy. Int J Hyperthermia 34:19-29|
|Jenkins, Samir V; Vang, Kieng B; Gies, Allen et al. (2018) Sample storage conditions induce post-collection biases in microbiome profiles. BMC Microbiol 18:227|
|Lo, Dennis; Kennedy, Joshua L; Kurten, Richard C et al. (2018) Modulation of airway hyperresponsiveness by rhinovirus exposure. Respir Res 19:208|
|Latham, Jacob I; Blevins, Jon S (2018) Generation of Conditional Mutants in Borrelia burgdorferi. Methods Mol Biol 1690:225-239|
|Lei, Mei G; Lee, Chia Y (2018) Repression of Capsule Production by XdrA and CodY in Staphylococcus aureus. J Bacteriol 200:|
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