Psychological and environmental stress, as well as disturbed sleep are important public health concerns and are independently known to significantly influence neurocognitive function. Compromised sleep is an essential risk factor and marker for chronic conditions that disproportionately affect urban minorities and further contribute to health disparities. There is a significant gap regarding sleep disparities, the potential role that the environment plays in such disparities, and how the relationship between sleep and neurocognitive performance may be moderated by psychological and social-environmental features. The goal of the proposed investigation is to establish a model where psychological and social-environmental features elicit sleep discontinuity that interferes with neurocognitive function. To accomplish this goal, we will employ multimodal approaches (e.g. clinical interviews, actigraphy, neurobehavioral tests, questionnaires). Psychological factors will be assessed by clinical interview and the role of social-environmental features by utilizing a battery of questionnaires to assess for stressful environmental factors. We will then have participants complete one week of actigraphy to assess for objective sleep continuity and habitual sleep. Finally, we will examine neurocognitive performance by utilizing a comprehensive neurocognitive battery. Study findings will identify specific psychological and environmental risk factors of neurocognitive performance related to habitual sleep. Further, these findings will be instrumental in moving the field toward a more useful integration of environmental, clinical, and neurobiological understanding that may improve quality of life and reduce the societal burden of sleep disparities.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103653-09
Application #
10247848
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Bernal, Federico
Project Start
2020-09-01
Project End
2022-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
9
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Delaware State University
Department
Type
DUNS #
114337629
City
Dover
State
DE
Country
United States
Zip Code
19901
Gawrysiak, Michael J; Grassetti, Stevie N; Greeson, Jeffrey M et al. (2018) The many facets of mindfulness and the prediction of change following mindfulness-based stress reduction (MBSR). J Clin Psychol 74:523-535
Sanchez, Karla R; Mersha, Mahlet D; Dhillon, Harbinder S et al. (2018) Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays. J Vis Exp :
Staib, Jennifer M; Della Valle, Rebecca; Knox, Dayan K (2018) Disruption of medial septum and diagonal bands of Broca cholinergic projections to the ventral hippocampus disrupt auditory fear memory. Neurobiol Learn Mem 152:71-79
Sadeh, Naomi; Spielberg, Jeffrey M; Logue, Mark W et al. (2018) Linking genes, circuits, and behavior: network connectivity as a novel endophenotype of externalizing. Psychol Med :1-9
Knox, Dayan; Stanfield, Briana R; Staib, Jennifer M et al. (2018) Using c-Jun to identify fear extinction learning-specific patterns of neural activity that are affected by single prolonged stress. Behav Brain Res 341:189-197
Boschen, K E; Keller, S M; Roth, T L et al. (2018) Epigenetic mechanisms in alcohol- and adversity-induced developmental origins of neurobehavioral functioning. Neurotoxicol Teratol 66:63-79
Lombardo, Joseph; Sun, Jianli; Harrington, Melissa A (2018) Rapid activity-dependent modulation of the intrinsic excitability through up-regulation of KCNQ/Kv7 channel function in neonatal spinal motoneurons. PLoS One 13:e0193948
Davis, Stephani A; Itaman, Sheed; Khalid-Janney, Christopher M et al. (2018) TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics. Neurosci Lett 678:8-15
Ruggiero, M J; Boschen, K E; Roth, T L et al. (2018) Sex Differences in Early Postnatal Microglial Colonization of the Developing Rat Hippocampus Following a Single-Day Alcohol Exposure. J Neuroimmune Pharmacol 13:189-203
Blaze, Jennifer; Asok, Arun; Borrelli, Kristyn et al. (2017) Intrauterine exposure to maternal stress alters Bdnf IV DNA methylation and telomere length in the brain of adult rat offspring. Int J Dev Neurosci 62:56-62

Showing the most recent 10 out of 97 publications