The Administrative Core for the Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) will lead, implement, and support the Center's primary activities. These activities are designed to accomplish the NPOD goal to create a nationally recognized center charged with (1) developing and sustaining a critical mass of investigators dedicated to obesity research and (2) leveraging Center discoveries to devise and implement effective strategies for the prevention of obesity-related diseases through the dietary manipulation of nutrient signaling pathways. The Administrative Core will provide the administrative and programmatic leadership and infrastructure necessary to ensure the NPOD functions efficiently and effectively and is responsive to emerging research opportunities. This will include implementing Center-wide activities - including biannual retreats, formal and informal training, and a seminar series - to create a collaborative research environment, promote the Center on a national level, and build a pool of talented doctoral and postdoctoral students in the laboratories of NPOD members. The Administrative Core will coordinate a faculty development plan that includes a research project program and pilot grant program designed to accelerate the transition of talented Project Leaders to independence and support the development of large multi-investigator grants, program projects, and training grants. The Administrative Core also includes Translational Coordinators with expertise in clinical studies and consumer behavior whose involvement will increase the rate and extent of translation of research discoveries into preventing disease. Finally, the Administrative Core will serve as a coordination point between Center members and the Center's Molecular Biology, Bioinformatics and Biostatistics Core (MB^C) services. The Administrative Core will support a research program and Bioinformatics Coordinators in the MB^C to develop innovative tools in nutrient signaling research and provide guidance in experimental design and data analysis.

Public Health Relevance

The Administrative Core will provide effective, efficient coordination of the proposed center in support of its goal to create a nationally recognized center dedicated to obesity research to devise and implement effective strategies to prevent obesity-related diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
1P20GM104320-01A1
Application #
8662968
Study Section
Special Emphasis Panel (ZGM1-TWD-C (C1))
Project Start
Project End
Budget Start
2014-08-05
Budget End
2015-05-31
Support Year
1
Fiscal Year
2014
Total Cost
$597,820
Indirect Cost
$201,913
Name
University of Nebraska Lincoln
Department
Type
DUNS #
555456995
City
Lincoln
State
NE
Country
United States
Zip Code
68583
Manca, Sonia; Upadhyaya, Bijaya; Mutai, Ezra et al. (2018) Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns. Sci Rep 8:11321
E Silva, Bruno Vieira Resende; Rad, Milad Ghiasi; Cui, Juan et al. (2018) A Mobile-Based Diet Monitoring System for Obesity Management. J Health Med Inform 9:
Fan, Rong; Toney, Ashley Mulcahy; Jang, Yura et al. (2018) Maternal n-3 PUFA supplementation promotes fetal brown adipose tissue development through epigenetic modifications in C57BL/6 mice. Biochim Biophys Acta Mol Cell Biol Lipids 1863:1488-1497
Nordgren, Tara M; Heires, Art J; Zempleni, Janos et al. (2018) Bovine milk-derived extracellular vesicles enhance inflammation and promote M1 polarization following agricultural dust exposure in mice. J Nutr Biochem 64:110-120
Martínez, Inés; Maldonado-Gomez, Maria X; Gomes-Neto, João Carlos et al. (2018) Experimental evaluation of the importance of colonization history in early-life gut microbiota assembly. Elife 7:
Zhang, Hanyuan; Vieira Resende E Silva, Bruno; Cui, Juan (2018) miRDis: a Web tool for endogenous and exogenous microRNA discovery based on deep-sequencing data analysis. Brief Bioinform 19:415-424
Leiferman, Amy; Shu, Jiang; Grove, Ryan et al. (2018) A diet defined by its content of bovine milk exosomes and their RNA cargos has moderate effects on gene expression, amino acid profiles and grip strength in skeletal muscle in C57BL/6 mice. J Nutr Biochem 59:123-128
Okla, Meshail; Zaher, Walid; Alfayez, Musaad et al. (2018) Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1? on White Adipocyte Browning. Inflammation 41:626-642
Chakrabarti, Subhadeep; Guha, Snigdha; Majumder, Kaustav (2018) Food-Derived Bioactive Peptides in Human Health: Challenges and Opportunities. Nutrients 10:
Kittana, Hatem; Quintero-Villegas, Maria I; Bindels, Laure B et al. (2018) Galactooligosaccharide supplementation provides protection against Citrobacter rodentium-induced colitis without limiting pathogen burden. Microbiology 164:154-162

Showing the most recent 10 out of 68 publications