Cardiovascular, renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the United States, especially in Mississippi which has the highest prevalence in the nation of these diseases. These disorders usually cluster together and are highly interdependent. Obesity and associated metabolic disorders, such as diabetes, are major causes of cardiovascular and renal disease. Abnormal kidney function is an important cause as well as a consequence of hypertension, a key risk factor for cardiovascular diseases such coronary artery disease and stroke. Understanding the complex relationships among cardiovascular, renal, and metabolic disorders and developing new therapeutic approaches requires a paradigm shift in research that incorporates multidisciplinary integrated approaches, combining the efforts of basic, clinical and population scientists. A major objective of this proposal is to develop an internationally recognized Cardiorenal and Metabolic Diseases Research Center (CMDRC) that brings together a multidisciplinary group of basic, clinical and population scientists working on a common synergistic theme, and to facilitate their collaborations.
The specific aims are: 1) To develop infrastructure and core facilities that foster excellence in basic, clinical, and population research in cardiorenal and metabolic diseases and increase competitiveness of junior investigators for independent funding from NIH and other national biomedical research programs.; 2) To develop mentoring and education programs and research support for promising junior investigators so that they can become productive, independent investigators who can successfully compete for NIH funding; 3) To achieve the specific aims of the research projects described by the junior investigators in this proposal, and to foster their career development; 4) To develop a pipeline of diverse predoctoral graduate students, medical students and postdoctoral fellows trained in cutting edge cardiorenal and metabolic diseases research so they become the next generation of researchers in this field; major emphasis will be placed on recruiting and mentoring underrepresented minority investigators through partnerships with local minority institutions; 5) To enhance collaborations and interactions among established investigators from multiple disciplines in cardiorenal and metabolic diseases at UMMC, as well as with external partners; 6) To strengthen cardiorenal and metabolic disease research at UMMC by recruiting new faculty with expertise in clinical and translational research and in emerging technologies, such as in vivo imaging, molecular genetics, bioinformatics, and systems analysis.
Cardiorenal and metabolic diseases are the leading causes of mortality and morbidity in the United States, especially in Mississippi which has the highest prevalence in the nation of these diseases. This is a critical area for research development in Mississippi, especially in view of th emerging opportunities to develop a comprehensive, multidisciplinary research center at UMMC that focuses on these major causes of mortality and morbidity. This proposal represents a plan to develop a unique, internationally recognized COBRE that is dedicated to improving lives through research, discovery and innovation.
| Wang, Lin; Quan, Nanhu; Sun, Wanqing et al. (2018) Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardium to ischaemia and reperfusion injury. Cardiovasc Res 114:805-821 |
| Lindsey, Merry L; Kassiri, Zamaneh; Virag, Jitka A I et al. (2018) Guidelines for measuring cardiac physiology in mice. Am J Physiol Heart Circ Physiol 314:H733-H752 |
| Li, Xuan; Liu, Jia; Hu, Haiyan et al. (2018) Dichloroacetate ameliorates cardiac dysfunction caused by ischemic insults through AMPK signal pathway- not only shifts metabolism. Toxicol Sci : |
| Lv, Wenshan; Fan, Fan; Wang, Yangang et al. (2018) Therapeutic potential of microRNAs for the treatment of renal fibrosis and CKD. Physiol Genomics 50:20-34 |
| Clemmer, John S; Pruett, William Andrew; Hester, Robert L et al. (2018) Role of the Heart in Blood Pressure Lowering During Chronic Baroreflex Activation: Insight from an in Silico Analysis. Am J Physiol Heart Circ Physiol : |
| Spann, Redin A; Lawson, William J; Bidwell 3rd, Gene L et al. (2018) Rodent vertical sleeve gastrectomy alters maternal immune health and fetoplacental development. Clin Sci (Lond) 132:295-312 |
| Shekhar, Shashank; Cunningham, Mark W; Pabbidi, Mallikarjuna R et al. (2018) Targeting vascular inflammation in ischemic stroke: Recent developments on novel immunomodulatory approaches. Eur J Pharmacol 833:531-544 |
| Mahajan, Gouri J; Vallender, Eric J; Garrett, Michael R et al. (2018) Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 82:177-186 |
| Lindsey, Merry L; Mouton, Alan J; Ma, Yonggang (2018) Adding Reg3? to the acute coronary syndrome prognostic marker list. Int J Cardiol 258:24-25 |
| Lindsey, Merry L; Jung, Mira; Hall, Michael E et al. (2018) Proteomic analysis of the cardiac extracellular matrix: clinical research applications. Expert Rev Proteomics 15:105-112 |
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