Our objective is to establish a highly interactive and dynamic group of investigators whose research focuses on understanding the functional role of epigenetic changes in human disease etiology and progression. We have proposed five new research projects all led by junior investigators, that will use molecular, biochemical, and computational biology approaches to study epigenetic regulation in different disease models. We will help define the role that environmental stressors play in disruption of the epigenome, and propose cutting edge, critical research in trans-generational models to understand how changes in the epigenomic may be linked to complex inheritance patterns and familial risk factors for high incidence diseases. These goals will be accomplished utilizing an integrative, systems biology approach to link epigenomic platforms such as global methylation arrays with next-generation RNA-sequencing and Chip-sequencing. To enhance the program further, we have included a translational component as a key facet of this COBRE, which is consistent with our global, strategic mission to address the needs of North Dakota's aging, largely rural population. Because epigenetic changes are potentially reversible, we believe that this research could lead to new treatment paradigms for devastating diseases such as cancer, drug addiction, and cardiovascular disease. The rationale for this center is that each individual brings unique expertise and key directions that together can help elucidate the role of epigenetic changes in various disease models. This center will nurture a focused group of investigators, and successful completion of our specific aims will result in the establishment of a collaborative and sustainable Center of Excellence in the Epigenomics of Development and Disease capable of attracting the brightest and most talented faculty, graduate students and postdoctoral fellows to conduct world class research in the burgeoning field of epigenetics. UND is fully committed to ensuring the growth and sustainability of this group even after the COBRE grant ends.
COBRE Phase I funding will (1) support five research projects that are initiated by young investigators, (2) centralized the bioinformatics core essential to our COBRE group as well as to other biomedical researchers, (3) support our administrative core that provides for a visiting speaker program, library acquisitions, an annual symposium/workshop and having an individualized mentoring program.
|Zhang, Ying; Darland, Diane; He, Yan et al. (2018) REDUCTION OF PM2.5 TOXICITY ON HUMAN ALVEOLAR EPITHELIAL CELLS A549 BY TEA POLYPHENOLS. J Food Biochem 42:|
|Hovde, Moriah J; Larson, Garret H; Vaughan, Roxanne A et al. (2018) Model systems for analysis of dopamine transporter function and regulation. Neurochem Int :|
|Sun, Yuyang; Schaar, Anne; Sukumaran, Pramod et al. (2018) TGF?-induced epithelial-to-mesenchymal transition in prostate cancer cells is mediated via TRPM7 expression. Mol Carcinog 57:752-761|
|Anderson, Cindy M; Gillespie, Shannon L; Thiele, Doria K et al. (2018) Effects of Maternal Vitamin D Supplementation on the Maternal and Infant Epigenome. Breastfeed Med 13:371-380|
|Bhattacharya, Atrayee; Kumar, Janani; Hermanson, Kole et al. (2018) The calcium channel proteins ORAI3 and STIM1 mediate TGF-? induced Snai1 expression. Oncotarget 9:29468-29483|
|Casselli, Timothy; Tourand, Yvonne; Scheidegger, Adam et al. (2018) DNA Methylation by Restriction Modification Systems Affects the Global Transcriptome Profile in Borrelia burgdorferi. J Bacteriol 200:|
|Foster, James D; Vaughan, Roxanne A (2017) Phosphorylation mechanisms in dopamine transporter regulation. J Chem Neuroanat 83-84:10-18|
|Dhasarathy, Archana; Roemmich, James N; Claycombe, Kate J (2017) Influence of maternal obesity, diet and exercise on epigenetic regulation of adipocytes. Mol Aspects Med 54:37-49|
|Casselli, Timothy; Qureshi, Humaira; Peterson, Elizabeth et al. (2017) MicroRNA and mRNA Transcriptome Profiling in Primary Human Astrocytes Infected with Borrelia burgdorferi. PLoS One 12:e0170961|
|Challasivakanaka, Sathya; Zhen, Juan; Smith, Margaret E et al. (2017) Dopamine transporter phosphorylation site threonine 53 is stimulated by amphetamines and regulates dopamine transport, efflux, and cocaine analog binding. J Biol Chem 292:19066-19075|
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