CORE B ABSTRACT The Biorepository Core has created a state-of-the-art and internationally competitive infrastructure for optimal management and oversight of human biospecimens to support the goals of the Center for Molecular Epidemiology. Biospecimens are the basis of the molecular characterization of both a disease and its host, and are crucial for modern molecular epidemiologic study. Careful handling of biologic samples with well-integrated de-identified specimen coding, tracking and data systems are thereby essential for applying cutting edge technologies to rapidly advance our understanding of the molecular basis of complex disease interactions. In Phase I of our Center, the Biorepository Core efficiently collected, processed, and aliquoted over 115,000 samples from over 21,000 unique and varied biospecimens by implementing robotic paired with manually triaged systems. A CLIA certified component of the Core occupying space renovated in our Phase I COBRE in the new Williamson Translational Research Building now is complete with charge back systems. We further constructed a secure, off-site Biospecimen Resource Facility to store our high quality samples for long-term access and future use. Building on our success in Phase I, we will expand our repertoire of centralized services and volume of samples while preserving rigorous collection, processing and analytic preparation (including nucleic acid extraction) standards for current and downstream analyses. A growing team of established investigators with multidisciplinary experience will provide education, training, consultation, and specialized expertise to the Center. We will enhance our interactive web-based databases and make them more widely available, and design integrated searchable platforms with linkages to clinical and epidemiologic data. In Phase II we will refine and phase-in charge back systems to accelerate our trajectory towards sustainablility and expand utilization of our unique Core resources to other IDeA programs and large-scaled regional, national, and international initiatives. Thus, we established a new coordinated, centralized Biorepository infrastructure that will continue to facilitate the scientific advancements of the Center research projects, and make significant contributions to cross-disciplinary translational research collaborations from the broader scientific community.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM104416-09
Application #
10091537
Study Section
Special Emphasis Panel (ZGM1)
Project Start
2013-03-01
Project End
2023-01-31
Budget Start
2021-02-01
Budget End
2022-01-31
Support Year
9
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Barr, Fiona D; Ochsenbauer, Christina; Wira, Charles R et al. (2018) Neutrophil extracellular traps prevent HIV infection in the female genital tract. Mucosal Immunol 11:1420-1428
Signes-Pastor, Antonio J; Cottingham, Kathryn L; Carey, Manus et al. (2018) Infants' dietary arsenic exposure during transition to solid food. Sci Rep 8:7114
Salas, Lucas A; Koestler, Devin C; Butler, Rondi A et al. (2018) An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray. Genome Biol 19:64
Deyssenroth, Maya A; Gennings, Chris; Liu, Shelley H et al. (2018) Intrauterine multi-metal exposure is associated with reduced fetal growth through modulation of the placental gene network. Environ Int 120:373-381
Romano, Megan E; Eliot, Melissa N; Zoeller, R Thomas et al. (2018) Maternal urinary phthalate metabolites during pregnancy and thyroid hormone concentrations in maternal and cord sera: The HOME Study. Int J Hyg Environ Health 221:623-631
Everson, Todd M; Punshon, Tracy; Jackson, Brian P et al. (2018) Cadmium-Associated Differential Methylation throughout the Placental Genome: Epigenome-Wide Association Study of Two U.S. Birth Cohorts. Environ Health Perspect 126:017010
Emond, Jennifer A; Karagas, Margaret R; Baker, Emily R et al. (2018) Better Diet Quality during Pregnancy Is Associated with a Reduced Likelihood of an Infant Born Small for Gestational Age: An Analysis of the Prospective New Hampshire Birth Cohort Study. J Nutr 148:22-30
Nachman, Keeve E; Punshon, Tracy; Rardin, Laurie et al. (2018) Opportunities and Challenges for Dietary Arsenic Intervention. Environ Health Perspect 126:84503
Moen, Erika L; Bynum, Julie P; Austin, Andrea M et al. (2018) Assessing Variation in Implantable Cardioverter Defibrillator Therapy Guideline Adherence With Physician and Hospital Patient-sharing Networks. Med Care 56:350-357
Braun, Joseph M; Chen, Aimin; Hoofnagle, Andrew et al. (2018) Associations of early life urinary triclosan concentrations with maternal, neonatal, and child thyroid hormone levels. Horm Behav 101:77-84

Showing the most recent 10 out of 131 publications