Many cancer patients and survivors suffer from adverse effects due to treatment that can arise both during and after the completion of cancer therapy. The COBRE Center for Studies of Host Response to Cancer Therapy supports investigators from various disciplines who 1) research the mechanisms by which cancer therapy causes adverse effects, 2) identify new methods for detecting side effects sooner, and 3) develop novel strategies to prevent or reduce side effects. The purpose of the Administrative Core (Core A) is to build a self-sustaining research Center by maximizing opportunities for investigators to succeed and by promoting interactions and synergy within the Center and with other research units in the institution. Core A will provide an efficient, integrated administrative infrastructure for the COBRE Center (Aim 1), accelerate scientific growth through faculty development and scientific advising (Aim 2), and expand and advance the Center toward self- sustainability (Aim 3). A primary function of the core is to provide administrative support for project leaders and to manage financial affairs for the Center as a whole. Core A ensures there is effective communication within and among the projects and cores. Additionally, the core provides the infrastructure for scientific advising and faculty development, which will encourage scientific progress for project leaders and will help integrate their efforts with those of other scientists on campus. With assistance of the External Advisory Committee, new project leaders will be recruited and selected to replace those who graduate from COBRE advisee status. The Center also will perform a systematic, objective evaluation of activities, project leaders and their research, scientific advising and faculty development programs, and core functions. This strategy will ensure the long-term success of the Center as an independent but well-integrated investigative unit on campus with a vibrant and synergistic research environment that comprehensively addresses the short-term and long-term side effects of cancer therapy.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM109005-06
Application #
10025388
Study Section
Special Emphasis Panel (ZGM1)
Project Start
2015-06-24
Project End
2025-05-31
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Type
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Wang, Lei; Fang, Bin; Fujiwara, Toshifumi et al. (2018) Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesis in vitro and in vivo. J Biol Chem 293:9248-9264
Harrill, Alison H; Lin, Haixia; Tobacyk, Julia et al. (2018) Mouse population-based evaluation of urinary protein and miRNA biomarker performance associated with cisplatin renal injury. Exp Biol Med (Maywood) 243:237-247
Zhang, Xin; Zhang, Suping; Liu, Xingui et al. (2018) Oxidation resistance 1 is a novel senolytic target. Aging Cell :e12780
Alexander, Tyler C; Butcher, Hannah; Krager, Kimberly et al. (2018) Behavioral Effects of Focal Irradiation in a Juvenile Murine Model. Radiat Res 189:605-617
He, Liu-Jun; Yang, Dong-Lin; Li, Shi-Qiang et al. (2018) Facile construction of fused benzimidazole-isoquinolinones that induce cell-cycle arrest and apoptosis in colorectal cancer cells. Bioorg Med Chem 26:3899-3908
Kiaei, Mahmoud; Balasubramaniam, Meenakshisundaram; Govind Kumar, Vivek et al. (2018) ALS-causing mutations in profilin-1 alter its conformational dynamics: A computational approach to explain propensity for aggregation. Sci Rep 8:13102
Koturbash, Igor (2018) 2017 Michael Fry Award Lecture When DNA is Actually Not a Target: Radiation Epigenetics as a Tool to Understand and Control Cellular Response to Ionizing Radiation. Radiat Res 190:5-11
Luo, Yi; Shao, Lijian; Chang, Jianhui et al. (2018) M1 and M2 macrophages differentially regulate hematopoietic stem cell self-renewal and ex vivo expansion. Blood Adv 2:859-870
Alexander, Tyler C; Simecka, Christy M; Kiffer, Frederico et al. (2018) Changes in cognition and dendritic complexity following intrathecal methotrexate and cytarabine treatment in a juvenile murine model. Behav Brain Res 346:21-28
Liu, Xingui; Wang, Yingying; Zhang, Xuan et al. (2018) Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation. Bioorg Med Chem 26:3925-3938

Showing the most recent 10 out of 81 publications