The overall objective of this COBRE application is to increase the quality and quantity of clinical, translational and implementation research in cardiometabolic diseases at Tulane University. This objective will be achieved by establishing a Center of Excellence for Clinical, Translational and Implementation Research in Cardiometabolic Diseases at Tulane University; developing and nurturing successful competitive independent investigators in clinical, translational and implementation research; motivating and facilitating multidisciplinary and interdisciplinary interaction and collaboration i the area of cardiometabolic disease research; and building and expanding the clinical and community-based research infrastructure at Tulane University and in Louisiana. We will recruit and mentor 7-10 junior faculty investigators and enhance their ability to successfully and independently compete for external peer-reviewed grants from the NIH and other national research agencies. We will provide scientific and administrative support to the junior faculty investigators through strong research core facilities so that they can accomplish the aims of the proposed five research projects. These research projects are focused on the prevention and treatment of cardiovascular diseases and metabolic risk factors through the generation and translation of knowledge from laboratory, clinical, and population studies to real- world clinical and public health settings. An internal advisory committee composed of mentors and core directors for this COBRE application are all strongly committed to this program and have outstanding track records in successfully conducting NIH-supported research and mentoring junior faculty. In addition, a prominent board of external advisors with exceptional research careers and experience in developing junior scientists will be selected to provide both guidance and evaluation of the progress of junior faculty investigators and the COBRE program as a whole. Mentors will use defined and proven methods to enhance the development and career success of the junior faculty. A series of program meetings, research seminars, and didactic grant-writing sessions will be provided to the junior faculty investigators to enhance their career development. Clinical research facilities and community outreach programs will be developed and expanded. The ultimate goal of this COBRE program is to establish an internationally recognized multidisciplinary research program in the etiology, prevention, and treatment of cardiometabolic diseases in Louisiana. Tulane University and its School of Public Health and Tropical Medicine and School of Medicine have all committed to the success of the proposed COBRE program. The proposed COBRE program is unique and novel because it emphasizes developing and nurturing clinical investigators and promoting clinical, population, and community- based research, which has a direct impact on patient care and disease prevention. This proposed COBRE application, if funded, will contribute to reducing the burden of cardiovascular diseases and metabolic risk factors, eliminating health disparities, and improving health both in Louisiana and the general US population.

Public Health Relevance

This COBRE application aims to increase the quality and quantity of clinical, translational and implementation research in cardiovascular diseases and metabolic risk factors at Tulane University by establishing a multidisciplinary center of excellence in cardiometabolic disease research and developing and nurturing successful competitive independent investigators in clinical, translational and implementation research. If funded, it will contribute to reducing the burden of cardiovascular diseases and metabolic risk factors, eliminating health disparities, and improving health both in Louisiana and the general US population.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
1P20GM109036-01A1
Application #
8813111
Study Section
Special Emphasis Panel (ZGM1-TWD-6 (C1))
Program Officer
Liu, Yanping
Project Start
2016-03-10
Project End
2021-02-28
Budget Start
2016-03-10
Budget End
2017-02-28
Support Year
1
Fiscal Year
2016
Total Cost
$2,557,500
Indirect Cost
$757,500
Name
Tulane University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
053785812
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Anderson, Christopher E; Hamm, L Lee; Batuman, Gem et al. (2018) The association of angiogenic factors and chronic kidney disease. BMC Nephrol 19:117
Zhou, Yu; Gao, Yunlong; Xu, Chao et al. (2018) A novel approach for correction of crosstalk effects in pathway analysis and its application in osteoporosis research. Sci Rep 8:668
Liu, Hui-Min; He, Jing-Yang; Zhang, Qiang et al. (2018) Improved detection of genetic loci in estimated glomerular filtration rate and type 2 diabetes using a pleiotropic cFDR method. Mol Genet Genomics 293:225-235
Liang, Xiao; Wu, CuiYan; Zhao, Hongmou et al. (2018) Assessing the genetic correlations between early growth parameters and bone mineral density: A polygenic risk score analysis. Bone 116:301-306
Yan, Yinkun; Zhang, Tao; Li, Shengxu et al. (2018) Black-White Difference in the Impact of Long-Term Blood Pressure From Childhood on Adult Renal Function: The Bogalusa Heart Study. Am J Hypertens 31:1300-1306
Liu, Li; Wen, Yan; Zhang, Lei et al. (2018) Assessing the Associations of Blood Metabolites With Osteoporosis: A Mendelian Randomization Study. J Clin Endocrinol Metab 103:1850-1855
Dorans, Kirsten S; Mills, Katherine T; Liu, Yang et al. (2018) Trends in Prevalence and Control of Hypertension According to the 2017 American College of Cardiology/American Heart Association (ACC/AHA) Guideline. J Am Heart Assoc 7:
Rice, Mary B; Li, Wenyuan; Dorans, Kirsten S et al. (2018) Exposure to Traffic Emissions and Fine Particulate Matter and Computed Tomography Measures of the Lung and Airways. Epidemiology 29:333-341
Li, Yumei; Xiang, Yang; Xu, Chao et al. (2018) Rare variant association analysis in case-parents studies by allowing for missing parental genotypes. BMC Genet 19:7
Gu, Xiaoying; Gu, Dongfeng; He, Jiang et al. (2018) Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study. Am J Hypertens 31:205-211

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