Survivors of brain injuries such as stroke and trauma often endure life-long disabilities, which span a spectrum of deficits and are associated with enormous individual and societal costs. There is an urgent need to develop effective interventions that can improve cognitive and motor outcomes, especially individualized approaches that target specific disruptions of brain physiology or circuits. The Center for Brain Recovery and Repair was established in Phase I as an interdisciplinary community of investigators to address these issues. A cohort of junior faculty successfully launched new independent research programs and have remained centrally active within the Center. Together with core leadership and other established investigators from diverse departments and programs across campus, we have established a highly interactive nucleus, working closely together in a physical home in Domenici Hall. Phase II activities build on this progress, by adding additional layers of mentored faculty, projects and resources required to ensure a self-sustaining, high impact Center. The Center will maintain its successful focus on moving laboratory discoveries about brain injury mechanisms into clinical application, and will therefore continue to emphasize a structure that promotes extensive mentoring and interaction between preclinical and clinical investigators. The physical home in Domenici Hall will be enhanced, to strengthen state-of-the-art facilities for both rodent studies and clinical interventions and assessment. Recordings from brain-injured patients in the neuro intensive care unit will also be studied in our Domenici Hall core facilities in Phase II, to address novel, actionable mechanisms earlier in the progression of brain injury. Innovative combinations of electrophysiology, imaging and cognitive assessment will be led by both the clinical and preclinical cores, with extensive cross-fertilization of ideas and approaches. An exciting set of projects using these cores will be led by junior faculty from different departments, addressing different severities and consequences of traumatic brain injury. An expanded pilot program, together with new partnerships and tenure-track hires will further increase the critical mass of investigators in the Center, supporting fiscal sustainability and increasing competitiveness for center-level support with additional extramural grants. The Center will leverage existing facilities and trainings at UNM, and expand valuable collaborations with regional IDeA programs for pipeline development and resource sharing. The significantly enhanced research capabilities will thus be available for a larger constituency of brain and behavioral health investigators in New Mexico, and investigators in other IDeA states. Such outcomes are expected to have an important positive impact, as they will greatly accelerate the discovery and adoption of interventions that are urgently needed for large numbers of individuals in IDeA communities living with the devastating consequences of brain injury.

Public Health Relevance

The Center for Brain Recovery and Repair will strengthen its interdisciplinary team of basic science and clinical investigators, with the goal of discovery of new and effective treatments to accelerate recovery of function for stroke and traumatic brain injury survivors. The Center will continue to develop innovative new research programs, supported by intensive mentoring and state-of-the-art resources. These efforts provide a hub for brain injury research in New Mexico, and aim to ultimately benefit the large number of New Mexicans and their families living with the consequences of debilitating brain injuries.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM109089-06
Application #
10026513
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Caldwell, Sheila
Project Start
2015-09-15
Project End
2025-06-30
Budget Start
2020-07-15
Budget End
2021-06-30
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of New Mexico Health Sciences Center
Department
Neurosciences
Type
Schools of Medicine
DUNS #
829868723
City
Albuquerque
State
NM
Country
United States
Zip Code
87131
Campbell, Richard A; Gorman, Stephanie A; Thoma, Robert J et al. (2018) Risk of Concussion During Sports Versus Physical Education Among New Mexico Middle and High School Students. Am J Public Health 108:93-95
Trofimov, Alexey O; Kalentiev, George; Karelsky, Michael et al. (2018) Cerebral Hemodynamics After Transcranial Direct Current Stimulation (tDCS) in Patients with Consequences of Traumatic Brain Injury. Adv Exp Med Biol 1072:59-62
Bragina, O A; Lara, D A; Nemoto, E M et al. (2018) Increases in Microvascular Perfusion and Tissue Oxygenation via Vasodilatation After Anodal Transcranial Direct Current Stimulation in the Healthy and Traumatized Mouse Brain. Adv Exp Med Biol 1072:27-31
Bikson, Marom; Brunoni, Andre R; Charvet, Leigh E et al. (2018) Rigor and reproducibility in research with transcranial electrical stimulation: An NIMH-sponsored workshop. Brain Stimul 11:465-480
MacQueen, David A; Minassian, Arpi; Kenton, Johnny A et al. (2018) Amphetamine improves mouse and human attention in the 5-choice continuous performance test. Neuropharmacology 138:87-96
Gustus, Kymberly C; Li, Lu; Chander, Praveen et al. (2018) Genetic inactivation of synaptosomal-associated protein 25 (SNAP-25) in adult hippocampal neural progenitors impairs pattern discrimination learning but not survival or structural maturation of newborn dentate granule cells. Hippocampus 28:735-744
Dobrzeniecki, Michael; Trofimov, Alex; Bragin, Denis E (2018) Cerebral Arterial Compliance in Traumatic Brain Injury. Acta Neurochir Suppl 126:21-24
Mayer, Andrew R; Kaushal, Mayank; Dodd, Andrew B et al. (2018) Advanced biomarkers of pediatric mild traumatic brain injury: Progress and perils. Neurosci Biobehav Rev 94:149-165
Bragin, Denis E; Bragina, Olga A; Hagberg, Sean et al. (2018) Pulsed Electromagnetic Field (PEMF) Mitigates High Intracranial Pressure (ICP) Induced Microvascular Shunting (MVS) in Rats. Acta Neurochir Suppl 126:93-95
Bragin, Denis E; Statom, Gloria L; Nemoto, Edwin M (2018) Induced Dynamic Intracranial Pressure and Cerebrovascular Reactivity Assessment of Cerebrovascular Autoregulation After Traumatic Brain Injury with High Intracranial Pressure in Rats. Acta Neurochir Suppl 126:309-312

Showing the most recent 10 out of 46 publications