In COBRE Phase I we established the Center for Research in Human Movement Variability (MOVCENTR) allowing the development of a strong critical mass of investigators and tremendous growth in terms of research infrastructure with world class facilities and resources such as the Biomechanics Research Building with its associated technologies and methodologies as well as the building?s upcoming expansion. In COBRE Phase II, we build on these foundational successes to maximize the likelihood of achieving an independent, sustainable, thematic, interdisciplinary center.
We aim to further strengthen the infrastructure and expertise base to explore the mechanisms of human movement variability in order to treat and prevent motor related disorders. Therefore, we propose to establish three new research cores, the Movement Analysis Core, the Nonlinear Analysis Core, and the Machining and Prototyping Core. We also aim to expand the critical mass of funded investigators supporting research in human movement variability. As such we propose four research projects that will be carried out under the Center?s umbrella. The project titles are: (1) The influence of prosthesis use on cortical activation and movement variability, (2) Longitudinal study of gait variability to predict falls in Parkinson disease, (3) Exoskeleton optimization for reducing gait variability in patients with Peripheral Artery Disease, and (4) Variability and specificity in reactive stabilization movements to diverse slip perturbations. These projects are led by strong junior investigators paired with senior clinical NIH-funded scientists as scientific advisors. Such a mentoring relationship is unique and has worked very well in enhancing the efficiency and quality of the clinical and translational research that is conducted in each research project under our thematic scientific focus.

Public Health Relevance

Human movement variability has been largely ignored as a source of important clinical information and has been treated as noise and error in the motor system. However, altered human movement variability is found increasingly in a variety of motor related disorders indicating reduced adaptive capacity in the neuromuscular system. The scientists in this Center determine optimal approaches for therapies grounded on the restoration of variability and complexity of movement that could be applied across a range of diseases.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Davani, Behrous
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Nebraska Omaha
Other Health Professions
Schools of Education
United States
Zip Code
Malcolm, Philippe; Galle, Samuel; Van den Berghe, Pieter et al. (2018) Exoskeleton assistance symmetry matters: unilateral assistance reduces metabolic cost, but relatively less than bilateral assistance. J Neuroeng Rehabil 15:74
Bruening, Dustin A; Pohl, Michael B; Takahashi, Kota Z et al. (2018) Midtarsal locking, the windlass mechanism, and running strike pattern: A kinematic and kinetic assessment. J Biomech 73:185-191
Kempski, Kelley; Awad, Louis N; Buchanan, Thomas S et al. (2018) Dynamic structure of lower limb joint angles during walking post-stroke. J Biomech 68:1-5
Haworth, Joshua; Stergiou, Nicholas (2018) Orderliness of Visual Stimulus Motion Mediates Sensorimotor Coordination. Front Physiol 9:1441
Childers, W Lee; Takahashi, Kota Z (2018) Increasing prosthetic foot energy return affects whole-body mechanics during walking on level ground and slopes. Sci Rep 8:5354
Leeder, Taylor; Fallahtafti, Farahnaz; Schieber, Molly et al. (2018) Optic flow improves step width and length in older adults while performing dual task. Aging Clin Exp Res :
Lanier, Amelia S; Knarr, Brian A; Stergiou, Nicholas et al. (2018) A Novel and Safe Approach to Simulate Cutting Movements Using Ground Reaction Forces. Sensors (Basel) 18:
Ray, Nicole T; Knarr, Brian A; Higginson, Jill S (2018) Walking speed changes in response to novel user-driven treadmill control. J Biomech 78:143-149
Rand, Troy J; Mukherjee, Mukul (2018) Transitions in persistence of postural dynamics depend on the velocity and structure of postural perturbations. Exp Brain Res 236:1491-1500
Groff, Boman R; Antonellis, Prokopios; Schmid, Kendra K et al. (2018) Stride-time variability is related to sensorimotor cortical activation during forward and backward walking. Neurosci Lett 692:150-158

Showing the most recent 10 out of 80 publications