The Administrative Core will continue to manage the Center for Translational Therapeutics (CTT) by attending to all fiscal, organizational, programmatic, career-development, communication, mentoring, and evaluation aspects of the Center.
The Specific Aims of this Core are: 1) To continue managing all the organizational, fiscal, scientific oversight, communication, reporting and evaluation aspects of the CTT. This will include interacting with other institutional components for the fiscal management of the CTT, the recruitment of new faculty into the Center, and the replacement of target faculty who have attained independence; organizing and supporting External Advisory Committee (EAC) visits; collecting, organizing and re-distributing as appropriate all the information needed for reporting and evaluation of the CTT by the EAC and producing the Annual Progress Report for NIGMS; and maintaining a web presence to connect the CTT with the participating institutions and with other IDeA programs/centers in and outside the state, the NIGMS, and the scientific community. 2) To continue fostering the career development of junior investigators, promote their progress toward independent funding, and support their continued participation in the CTT, once they attain independence. This will include organizing and managing all CTT meetings, seminars, symposia and other similar activities; mediating communication for mentoring activities and for the review of drafts of grant proposals and manuscripts; and ultimately creating a research environment conducive to the development of young scientists and to accelerating discoveries with inherent applicability in the clinical setting. 3) To promote the formation of teams of investigators and continue promoting the generation of new ideas within the CTT and connecting the CTT with surrounding programs. The pilot project program will provide funding for targeted projects each year, aiming at promoting team science, and generating preliminary data leading to applications for multi-investigator and SBIR/STTR grant proposals, alongside the traditional individual R01 or equivalent. In addition to targeted funding for collaborative teams, the CTT will implement specific strategies to promote collaborations, including (but not limited to) targeted hires to complement existing strengths; tailored mentoring and training; structured opportunities for brainstorming and the generation of ideas; and support for the submission of team-based grant proposals. The Administrative Core will be managed by the PI/Center Director, with a half-time Scientific Coordinator and a full-time Program Manager; and by the Steering Committee composed of the PI, Scientific Coordinator and Core Leaders. An Internal Advisory Committee and a cadre of Mentors will assist the PI in the management of the program. In addition, an External Advisory Committee will provide external evaluation, and support the PI in the scientific development of the Center.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM109091-07
Application #
9978914
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of South Carolina at Columbia
Department
Type
DUNS #
041387846
City
Columbia
State
SC
Country
United States
Zip Code
29208
Liang, Jiaxin; Chen, Mengqian; Hughes, Daniel et al. (2018) CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases. Cancer Res 78:6594-6606
Chukwurah, Evelyn; Patel, Rekha C (2018) Stress-induced TRBP phosphorylation enhances its interaction with PKR to regulate cellular survival. Sci Rep 8:1020
Singh, Priyanka; Jenkins, Laura M; Horst, Ben et al. (2018) Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis. Cancer Res 78:2978-2989
Wyatt, Michael D; Reilly, Nicole M; Patel, Shikha et al. (2018) Thiopurine-induced mitotic catastrophe in Rad51d-deficient mammalian cells. Environ Mol Mutagen 59:38-48
Serrao, Anne; Jenkins, Laura M; Chumanevich, Alexander A et al. (2018) Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer. Oncogene 37:4792-4808
Varadaraj, Archana; Magdaleno, Carina; Mythreye, Karthikeyan (2018) Deoxycholate Fractionation of Fibronectin (FN) and Biotinylation Assay to Measure Recycled FN Fibrils in Epithelial Cells. Bio Protoc 8:
Liu, Changlong; Banister, Carolyn E; Weige, Charles C et al. (2018) PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids. Proc Natl Acad Sci U S A 115:E5066-E5075
Yu, Jin; Zhu, Hong; Taheri, Saeid et al. (2018) Impact of nutrition on inflammation, tauopathy, and behavioral outcomes from chronic traumatic encephalopathy. J Neuroinflammation 15:277
Jenkins, Laura M; Horst, Ben; Lancaster, Carly L et al. (2018) Dually modified transmembrane proteoglycans in development and disease. Cytokine Growth Factor Rev 39:124-136
Alam, Amer; Küng, Raphael; Kowal, Julia et al. (2018) Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1. Proc Natl Acad Sci U S A 115:E1973-E1982

Showing the most recent 10 out of 49 publications