Abstract

Stroke is the fifth leading cause of death and the leading cause of disability among Americans and developing effective treatments for stroke remains a pressing need. The Experimental Stroke Core (ESC) is an essential core for the West Virginia University (WVU) Stroke CoBRE that provides unique expertise and develops novel tools and stroke animal models to enhance the effectiveness of stroke researchers. The overall goal for the ESC is to provide the expertise, training, instrumentation, and resources for the incorporation of animal models of stroke into the research of junior investigators participating in the WVU Stroke CoBRE and researchers in the greater WVU neuroscience and cardiovascular research community. The four proposed specific aims of the ESC will help advance the WVU Stroke CoBRE to a Center of Excellence and, thereby, achieve sustainability after CoBRE funding ends.
Aim 1 : To provide the expertise, instrumentation and resources to produce strokes in rodent models.
Aim 2 : To provide processes by which users can access the ESC expertise and resources.
Aim 3 : To provide mentoring and training in experimental stroke research.
Aim 4 : To develop new animal models and implement a sustainability business plan for the Experimental Stroke Core. Achieving these specific aims will provide a highly functioning ESC for the research community and bridge a transition of CoBRE- supported-ESC to an independent core facility.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM109098-06A1
Application #
10025930
Study Section
Special Emphasis Panel (ZGM1)
Project Start
2014-09-08
Project End
2025-05-31
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
West Virginia University
Department
Type
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506

  Publications

Robinson, Andria R; Yousefzadeh, Matthew J; Rozgaja, Tania A et al. (2018) Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biol 17:259-273
Branyan, Kayla W; Devallance, Evan R; Lemaster, Kent A et al. (2018) Role of Chronic Stress and Exercise on Microvascular Function in Metabolic Syndrome. Med Sci Sports Exerc 50:957-966
Schmidt, Heidi M; Kelley, Eric E; Straub, Adam C (2018) The impact of xanthine oxidase (XO) on hemolytic diseases. Redox Biol 21:101072
Povroznik, Jessica M; Ozga, Jenny E; Vonder Haar, Cole et al. (2018) Executive (dys)function after stroke: special considerations for behavioral pharmacology. Behav Pharmacol 29:638-653
Sheppard, Jordan G; Frazier, Keely R; Saralkar, Pushkar et al. (2018) Disulfiram-based disulfides as narrow-spectrum antibacterial agents. Bioorg Med Chem Lett 28:1298-1302
Sprenkle, Neil T; Lahiri, Anirudhya; Simpkins, James W et al. (2018) Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system. J Neurochem :
O'Connell, Grant C; Treadway, Madison B; Tennant, Connie S et al. (2018) Shifts in Leukocyte Counts Drive the Differential Expression of Transcriptional Stroke Biomarkers in Whole Blood. Transl Stroke Res :
Brooks, Steven; Brnayan, Kayla W; DeVallance, Evan et al. (2018) Psychological stress-induced cerebrovascular dysfunction: the role of metabolic syndrome and exercise. Exp Physiol 103:761-776
Brichacek, Allison L; Brown, Candice M (2018) Alkaline phosphatase: a potential biomarker for stroke and implications for treatment. Metab Brain Dis :
Shumar, Stephanie A; Kerr, Evan W; Geldenhuys, Werner J et al. (2018) Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform. J Biol Chem 293:4134-4148

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