Stroke is the fifth leading cause of death and the leading cause of disability among Americans and developing effective treatments for stroke remains a pressing need. The Experimental Stroke Core (ESC) is an essential core for the West Virginia University (WVU) Stroke CoBRE that provides unique expertise and develops novel tools and stroke animal models to enhance the effectiveness of stroke researchers. The overall goal for the ESC is to provide the expertise, training, instrumentation, and resources for the incorporation of animal models of stroke into the research of junior investigators participating in the WVU Stroke CoBRE and researchers in the greater WVU neuroscience and cardiovascular research community. The four proposed specific aims of the ESC will help advance the WVU Stroke CoBRE to a Center of Excellence and, thereby, achieve sustainability after CoBRE funding ends.
Aim 1 : To provide the expertise, instrumentation and resources to produce strokes in rodent models.
Aim 2 : To provide processes by which users can access the ESC expertise and resources.
Aim 3 : To provide mentoring and training in experimental stroke research.
Aim 4 : To develop new animal models and implement a sustainability business plan for the Experimental Stroke Core. Achieving these specific aims will provide a highly functioning ESC for the research community and bridge a transition of CoBRE- supported-ESC to an independent core facility.
| Tok, Fatih; Kocyigit-Kaymakcioglu, Bedia; Tabanca, Nurhayat et al. (2018) Synthesis and structure-activity relationships of carbohydrazides and 1,3,4-oxadiazole derivatives bearing an imidazolidine moiety against the yellow fever and dengue vector, Aedes aegypti. Pest Manag Sci 74:413-421 |
| Popov, Anton; Olesh, Erienne V; Yakovenko, Sergiy et al. (2018) A novel method of identifying motor primitives using wavelet decomposition. Int Conf Wearable Implant Body Sens Netw 2018:122-125 |
| DeVallance, Evan; Branyan, Kayla W; Lemaster, Kent et al. (2018) Aortic dysfunction in metabolic syndrome mediated by perivascular adipose tissue TNF?- and NOX2-dependent pathway. Exp Physiol 103:590-603 |
| Nair, Rajesh R; Geldenhuys, Werner J; Piktel, Debbie et al. (2018) Novel compounds that target lipoprotein lipase and mediate growth arrest in acute lymphoblastic leukemia. Bioorg Med Chem Lett 28:1937-1942 |
| Robinson, Andria R; Yousefzadeh, Matthew J; Rozgaja, Tania A et al. (2018) Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biol 17:259-273 |
| Branyan, Kayla W; Devallance, Evan R; Lemaster, Kent A et al. (2018) Role of Chronic Stress and Exercise on Microvascular Function in Metabolic Syndrome. Med Sci Sports Exerc 50:957-966 |
| Schmidt, Heidi M; Kelley, Eric E; Straub, Adam C (2018) The impact of xanthine oxidase (XO) on hemolytic diseases. Redox Biol 21:101072 |
| Povroznik, Jessica M; Ozga, Jenny E; Vonder Haar, Cole et al. (2018) Executive (dys)function after stroke: special considerations for behavioral pharmacology. Behav Pharmacol 29:638-653 |
| Sheppard, Jordan G; Frazier, Keely R; Saralkar, Pushkar et al. (2018) Disulfiram-based disulfides as narrow-spectrum antibacterial agents. Bioorg Med Chem Lett 28:1298-1302 |
| Sprenkle, Neil T; Lahiri, Anirudhya; Simpkins, James W et al. (2018) Endoplasmic reticulum stress is transmissible in vitro between cells of the central nervous system. J Neurochem : |
Showing the most recent 10 out of 61 publications
