The Translational Genomics Core (TGC) of the Louisiana Cancer Research Center (LCRC), initially created by the School of Medicine and the COBRE ?Mentoring Translational Researchers in Louisiana? has now been incorporated into the institution to provide state-of-the-art generation sequencing (NGS) including whole transcriptome, RNASeq, whole exome sequencing, and SNP analysis, and transcriptional profiling to investigators at LSU Health Sciences Center and other surrounding research facilities. The TGC is expanding its services with a new platform for ChIP-Seq optimization, single-cell sequencing, and single-molecule sequencing. The TGC has served multiple projects local, national and international projects in cancer and other diseases. In addition, TGC working in close collaboration with the Biostatistics and Bioinformatics Core (BBC) will ensure state-of-the-art biostatistics and bioinformatics analyses of data from the research and clinical studies. The PDs of the CTVO, Dr. Reiss and Dr. Parsons, negotiated with the TGC director, Dr. Zabaleta, privileged access for promising junior investigators (PJIs), which includes discounts for services, comprehensive training, equipment use, trouble shutting protocols, and the help in analyzing the data (see LOS by Zabaleta). The TGC's long-term goal is to become the regional genomics reference center serving basic, translational and clinical researchers with state-of-the-art technology, training, and service. All these new developments will additionally strengthen the research projects and the pilot studies led by PJIs, all of which contain a strong translational component.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM121288-02
Application #
9545024
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2018-06-01
Budget End
2019-05-31
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Louisiana State Univ Hsc New Orleans
Department
Type
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Mills, Kylie L; Gomes, Angelica M; Standlee, Courtney R et al. (2018) Gas6 is dispensable for pubertal mammary gland development. PLoS One 13:e0208550
Lassak, Adam; Dean, Mathew; Wyczechowska, Dorota et al. (2018) Molecular and Structural Traits of Insulin Receptor Substrate 1/LC3 Nuclear Structures and Their Role in Autophagy Control and Tumor Cell Survival. Mol Cell Biol 38:
Qiao, Jing; Cao, Yueyu; Zabaleta, Jovanny et al. (2018) Regulation of Virus-Associated Lymphoma Growth and Gene Expression by Bacterial Quorum-Sensing Molecules. J Virol 92:
Dai, Lu; Del Valle, Luis; Miley, Wendell et al. (2018) Transactivation of human endogenous retrovirus K (HERV-K) by KSHV promotes Kaposi's sarcoma development. Oncogene 37:4534-4545
Dai, Lu; Smith, Charles D; Foroozesh, Maryam et al. (2018) The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo. Int J Cancer 142:2153-2162
Dai, Lu; Qiao, Jing; Del Valle, Luis et al. (2018) KSHV co-infection regulates HPV16+ cervical cancer cells pathogenesis in vitro and in vivo. Am J Cancer Res 8:708-714
Lin, Zhen; Nguyen, Christian; Xu, Beibei et al. (2018) Interleukin-17A in the Pathogenesis of Lung Adenocarcinoma. Ann Am Thorac Soc 15:S125
Ungerleider, Nathan; Concha, Monica; Lin, Zhen et al. (2018) The Epstein Barr virus circRNAome. PLoS Pathog 14:e1007206
Dai, Lu; Zhao, Mengmeng; Jiang, Wei et al. (2018) KSHV co-infection, a new co-factor for HPV-related cervical carcinogenesis? Am J Cancer Res 8:2176-2184
Dai, Lu; Lin, Zhen; Jiang, Wei et al. (2017) Lipids, lipid metabolism and Kaposi's sarcoma-associated herpesvirus pathogenesis. Virol Sin 32:369-375

Showing the most recent 10 out of 13 publications