This is a 5 year competitive renewal application of the Hawai'i EXPORT Center (NEC;P20 MD173) which seeks to establish a new Center for Native and Pacific Health Disparities Research. The proposed Center will serve as a regional focal point for research, research training and community engagement aimed at cardiometabolic health &health disparities among Native Hawaiians (NHs), Alaska Natives (ANs) &other Pacific Peoples (PPs) including Filipinos, Samoans, &Tongans, etc. Cardiometabolic risk encompasses the clustering of risk factors, such as dyslipidemia, hypertension, hyperglycemia, central adiposity &insulin resistance, which predisposes individuals to cardiovascular disease (CVD) &Type 2 diabetes (DM-2). Among NHs, ANs &PPs, cardiometabolic morbidity &mortality exceeds rates in the general U.S. population &recent studies suggest that racial/ethnic misclassification or aggregation may even be masking the magnitude of cardiometaboliclifornia. The Center's specific aims are to: 1) Refine the Center's administrative &fiscal infrastructure to synerqize research studies, research training and community partnerships focused on NHs, ANs &PPs cardiometabolic health and health disparities. 2) Conduct hypothesis-driven research on cardiometabolic disparities of high scientific merit &community priority to NHs, ANs &PPs. 3) Mentor investigators to conduct innovative research studies &embark on careers that will contribute to reducing cardiometabolic disparities in NHs, ANs &PPs. 4) Use CBPR approaches that foster co-learning processes for conducting scientific research on cardiometabolic health &health disparities in NHs, ANs &PPs. The Center will feature three 5-yr studies: 1) The HULA Study: is a randomized control trial comparing a hula intervention to usual care in patient's post-CABG surgery. 2) The Metabolic Syndrome (MS) study in Filipino, NH and Samoan Youth: is an epidemiological study that will charactern triglyceride &apo-B lipoprotin regulation using in vivo animal models. A robust program of Research Training and Mentorship will serve to 'incubate'new &emerging investigators pursuing careers in health disparities research. Community engagement projects in Hawai'i &California will assess optimal strategies for health information dissemination &participation among NH, AN &PP communities to improve cardiometabolic health &eliminate health disparities. In summary, the Center for Native and Pacific Health Disparities Research proposes to build on the success of the HEC &will improve and expand its partnerships with Alaska &California using CBPR approaches that combines both community wisdom &scientific rigor to advance the evidence-base on cardiometabolic health &health disparities among NHs, ANs &PPs. The public health impact of the Center's activities is the potential to add new insights into the growing epidemic of obesity, DM-2 and CVD risk.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Exploratory Grants (P20)
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Study Section
Special Emphasis Panel (ZRG1-DIG-B (52))
Program Officer
Tabor, Derrick C
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University of Hawaii
Internal Medicine/Medicine
Schools of Medicine
United States
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Sentell, Tetine; Ahn, Hyeong Jun; Miyamura, Jill et al. (2018) Thirty-Day Inpatient Readmissions for Asian American and Pacific Islander Subgroups Compared With Whites. Med Care Res Rev 75:100-126
Hulgan, Todd; Ramsey, Benjamin S; Koethe, John R et al. (2018) Relationships between Adipose Mitochondrial Function, Serum Adiponectin, and Insulin Resistance in Persons with HIV after 96 weeks of Antiretroviral Therapy. J Acquir Immune Defic Syndr :
Nakagawa, Kazuma; Seto, Todd B (2018) Thrombus ""Squeezing"" Through Patent Foramen Ovale After Traumatic Brain Injury. Neurocrit Care :
Malabed, Jhon Michael; Taira, Deborah A; Seto, Todd B et al. (2018) 2017 Writing Contest Undergraduate Winner: Pathways to Preventable Hospitalizations for Filipino Patients with Diabetes and Heart Disease in Hawai'i. Hawaii J Med Public Health 77:155-160
Sentell, Tetine Lynn; Shen, Chengli; Landsittel, Doug et al. (2018) Racial/Ethnic Differences in Those Accompanying Medicare Patients to the Doctor: Insights from the 2013 Medicare Current Beneficiary's Survey. J Immigr Minor Health 20:776-783
Seto, Jason; Davis, James; Taira, Deborah Ann (2018) Examining the Association Between Different Aspects of Socioeconomic Status, Race, and Disability in Hawaii. J Racial Ethn Health Disparities 5:1247-1253
Wey, Andrew; Davis, James; Juarez, Deborah Taira et al. (2018) Distinguishing between primary and secondary racial identification in analyses of health disparities of a multiracial population in Hawaii. Ethn Health 23:233-248
Kaholokula, Joseph Keawe'aimoku; Ing, Claire Townsend; Look, Mele A et al. (2018) Culturally responsive approaches to health promotion for Native Hawaiians and Pacific Islanders. Ann Hum Biol 45:249-263
Nakagawa, Kazuma; King, Sage L; Seto, Todd B et al. (2018) Disparities in Functional Outcome After Intracerebral Hemorrhage Among Asians and Pacific Islanders. Front Neurol 9:186
Nakagawa, Kazuma; King, Sage L; Seto, Todd B (2018) Optimal Hematoma Volume Cut Points to Predict Functional Outcome After Basal Ganglia and Thalamic Hemorrhages. Front Neurol 9:291

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