Metabolic syndrome, and the associated type 2 diabetes, has become an epidemic in all 'westernized'world cultures, with minority populations at the greatest risk. While considered a disease of mid-age,incidence in pediatric populations is rapidly increasing. Current risk estimates by the CDC predict thatchildren bom in 2000 will have a 50% risk of developing type 2 diabetes, with an average loss of 20 yrs ofquality adjusted life. The rapid increases are due to inactivity, and easy availability of calorie-rich food,however there are significant genetic contributions to each of the five component risk factors (bloodpressure, glycemic index, HDL, LDL, waist circumference). Identification of genetic risk factors are felt to beimportant both for understanding of the biology of predispositions, and also to enable more personalizedinterventions to targeted populations.We present preliminary data on identification of the first major metabolic syndrome risk genetic locus. A15kb haplotype was identified that contains multiple SNPs, each in evolutionary conserved regulatoryregions. Haplotype 2 simultaneously alters three regions away from evolutionary conserved ancestralsequence. Testing of 6 subject cohorts, totaling 9,200 individuals, for this haplotype shows that Haplotype 2confers protection from metabolic syndrome (relative risk RR=0.5 p<0.0001). We have found manyadditional phenotypes associated with this locus, including muscle strength, bone volume, adiposity,circulating insulin, circulating glucose, and insulin resistance. We have also shown that the componentSNPs alter enhancer and represser function differentially in bone, muscle, and fat cells.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Exploratory Grants (P20)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-DIG-E (52))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Howard University
United States
Zip Code
Buchanan, Cara R Muñoz; Tomaszewski, Kathy; Chung, Shang-En et al. (2018) Why Didn't You Text Me? Poststudy Trends From the DepoText Trial. Clin Pediatr (Phila) 57:82-88
Stamato, Lydia; Johnson, Sarah Lindstrom; Cheng, Tina L (2018) ""I Used to Be Wild"": Adolescent Perspectives on the Influence of Family, Peers, School, and Neighborhood on Positive Behavioral Transition. Youth Soc 50:49-74
Ramsey, Alexandra; Lanzo, Erin; Huston-Paterson, Hattie et al. (2018) Increasing Patient Portal Usage: Preliminary Outcomes From the MyChart Genius Project. J Adolesc Health 62:29-35
Carlin, Rebecca F; Abrams, Anna; Mathews, Anita et al. (2018) The Impact of Health Messages on Maternal Decisions About Infant Sleep Position: A Randomized Controlled Trial. J Community Health 43:977-985
Seetharaman, Sujatha; Samples, Cathryn L; Trent, Maria (2017) Did the 2011 AAP recommendations on youth HIV testing change practice? Trends from a large urban adolescent program. HIV AIDS (Auckl) 9:95-100
Hodgkinson, Stacy; Godoy, Leandra; Beers, Lee Savio et al. (2017) Improving Mental Health Access for Low-Income Children and Families in the Primary Care Setting. Pediatrics 139:
Moon, Rachel Y; Mathews, Anita; Joyner, Brandi L et al. (2017) Health Messaging and African-American Infant Sleep Location: A Randomized Controlled Trial. J Community Health 42:1-9
Zurca, Adrian D; Fisher, Kiondra R; Flor, Remigio J et al. (2017) Communication With Limited English-Proficient Families in the PICU. Hosp Pediatr 7:9-15
Many, Gina M; Lutsch, Andrea; Connors, Kimberly E et al. (2016) Examination of Lifestyle Behaviors and Cardiometabolic Risk Factors in University Students Enrolled in Kinesiology Degree Programs. J Strength Cond Res 30:1137-46
Lindstrom Johnson, Sarah; Reichenberg, Raymond; Bradshaw, Catherine P et al. (2016) Caregiver and Adolescent Discrepancies in Perceptions of Violence and Their Associations with Early Adolescent Aggression. J Youth Adolesc 45:2125-37

Showing the most recent 10 out of 84 publications