In recent years, the overall AIDS and AIDS associated cancer mortality in the U.S. has significantly decreased, but the decrease has not been consistent across all populations. Due to an array of barriers to care, minorities and poor people who are infected with the human immunodeficiency virus type I (HIV) and various other sexually transmitted diseases (i.e., human herpes virus type 8 [HHV-8] and human papillomavirus [HPV]) have not benefited from advances in the treatment of HIV and HIV associated diseases as other groups. Minorities are acquiring HIV (and other sexually transmitted infectious diseases) at much higher rates than observed in Caucasians. African American (AA) women are the fastest growing group of HIV positive individuals. Our proposal addresses this issue by developing a partnership between the researchers, the established health care facilities, community outreach groups and education initiatives to close the gaps in these philosophical differences, realize the limitations, and reach out to the medical community, researcher, as well as the public to reduce the health disparities. It focuses specifically on consolidation of the resources between various groups to maximize health care for the underserved populations in SC. We believe that the outcome of this study will benefit all the underserved groups in the nation The five specific aims of this project are: 1) to establish a molecular virology laboratory to serve as a core research resource for the EXPORT collaborating researchers 2) to collect and provide data on HIV-1 in HIV-1 seropositive individuals recruited for participation in the projects of Drs. Hand and Phillips and Drs. Stoskopf and Geslani, 3) to provide quantitative assessment of HPV 16 and 18 E7 mRNA, sequencing and genotyping of HPV, and HPV viral load from Pap smears collected from the other full research project headed by Drs. Creek and Pirisi, 4) to determine HHV-8 viral loads in HIV-1 seropositive individuals for this research project and then to 5) investigate any correlation(s) between the development of full blown AIDS, and KS.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
5P20MD001770-04
Application #
7648050
Study Section
Special Emphasis Panel (ZMD1)
Project Start
Project End
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
4
Fiscal Year
2008
Total Cost
$220,839
Indirect Cost
Name
University of South Carolina at Columbia
Department
Type
DUNS #
041387846
City
Columbia
State
SC
Country
United States
Zip Code
29208
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Spiryda, Lisa Beth; Whitaker, Kara M; Messersmith, Amy et al. (2016) Clinical Utility of Molecular Biomarkers in Cervical Squamous Intraepithelial Lesions in a Young Adult Population. J Low Genit Tract Dis 20:26-30
Anderson, Erin L; Banister, Carolyn E; Kassler, Susannah et al. (2016) Human Papillomavirus Type 16 L2 DNA Methylation in Exfoliated Cervical Cells From College-Age Women. J Low Genit Tract Dis 20:332-7
Wilson, Sacoby; Burwell-Naney, Kristen; Jiang, Chengsheng et al. (2015) Assessment of sociodemographic and geographic disparities in cancer risk from air toxics in South Carolina. Environ Res 140:562-8
Banister, Carolyn E; Messersmith, Amy R; Cai, Bo et al. (2015) Disparity in the persistence of high-risk human papillomavirus genotypes between African American and European American women of college age. J Infect Dis 211:100-8
Xu, Hanwen; Pirisi, Lucia; Creek, Kim E (2015) Six1 overexpression at early stages of HPV16-mediated transformation of human keratinocytes promotes differentiation resistance and EMT. Virology 474:144-53
Rice, LaShanta J; Brandt, Heather M; Hardin, James W et al. (2015) Exploring perceptions of cancer risk, neighborhood environmental risks, and health behaviors of blacks. J Community Health 40:419-30
Graves, Christian A; Jones, Ashley; Reynolds, Justin et al. (2015) Neuroendocrine Merkel cell carcinoma is associated with mutations in key DNA repair, epigenetic and apoptosis pathways: a case-based study using targeted massively parallel sequencing. Neuroendocrinology 101:112-9
Bellinger, Jessica D; Millegan, Whitney; Abdalla, Azza E (2015) ""I'm not ashamed to talk on it!"": African-American women's decisions about cervical cancer prevention and control in South Carolina. Womens Health Issues 25:120-7

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