The Center for Cancer Research and Therapeutic Development (CCRTD) was established in 1999 at Clark Atlanta University to carry-out basic research in cancer biology and drug discovery. In 2004, the CCRTD decided to concentrate in the area of prostate cancer due to disproportionately higher incidence and mortality rate of this disease in African-American men. The current proposal requests support to continue the Center of Excellence in Prostate Cancer Research, Education and Community Education. The main objectives of this center will be 1) To carry out high quality basic research in cell and molecular biology of prostate cancer and to identify underlying biological reasons for racial disparities, 2) To continue our training program for undergraduate and graduate students to provide research training in the area of prostate cancer and hence increase the number of minority (primarily African American) scientists in this area of research, 3) To expand the community-based educational program for raising awareness on prevention, screening, early detection and treatment of prostate cancer. These goals will be achieved in collaboration with the Clark Atlanta University Division of Communication Arts, Midtown Urology Educational Foundation, Saint Joseph's Hospital Men's Health and Wellness Center, and other community organizations. In the Research Core, we propose three research projects focusing on prostate cancer cell and molecular biology and racial disparities. In the Training Core, we are requesting support for training of four graduate and six undergraduate students in the area of cancer biology and community service. In the Community Outreach/Education Core, we are requesting support to expand upon the community outreach and educational activities to include a larger media arena and coverage. The overall activities of the center will be monitored by the Administrative Core. The activities of the Administrative Core will be overseen by the Institutional (lAC), External (EAC) and Local External (LEAC) Advisory Committees. The long term goals of the center will be to understand the biology of prostate cancer, to increase the number of African-American scientists in cancer research, and to educate the African-American community in the areas of prostate cancer prevention, early detection and treatment.

Public Health Relevance

Prostate cancer affects the African-American community disproportionately. There is an increased incidence/mortality rate for African-American men, however the reason for this is unknown. The Center for Cancer Research and Therapeutic Development is committed to focus on the impact of this health disparity within the African-American community

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
4P20MD002285-10
Application #
9066515
Study Section
Special Emphasis Panel (ZMD1)
Program Officer
Das, Rina
Project Start
2007-10-01
Project End
2017-05-31
Budget Start
2016-06-01
Budget End
2017-05-31
Support Year
10
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Clark Atlanta University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
065325177
City
Atlanta
State
GA
Country
United States
Zip Code
30314
Hawsawi, Ohuod; Henderson, Veronica; Burton, Liza J et al. (2018) High mobility group A2 (HMGA2) promotes EMT via MAPK pathway in prostate cancer. Biochem Biophys Res Commun 504:196-202
Elliott, Bethtrice; Zackery, DeAdra L; Eaton, Vanessa A et al. (2018) Ethnic differences in TGF?-signaling pathway may contribute to prostate cancer health disparity. Carcinogenesis 39:546-555
Kimbrough-Allah, Mawiyah N; Millena, Ana C; Khan, Shafiq A (2018) Differential role of PTEN in transforming growth factor ? (TGF-?) effects on proliferation and migration in prostate cancer cells. Prostate 78:377-389
Scarlett, Kisha A; White, El-Shaddai Z; Coke, Christopher J et al. (2018) Agonist-induced CXCR4 and CB2 Heterodimerization Inhibits G?13/RhoA-mediated Migration. Mol Cancer Res 16:728-739
Caggia, Silvia; Chunduri, HimaBindu; Millena, Ana C et al. (2018) Novel role of Gi?2 in cell migration: Downstream of PI3-kinase-AKT and Rac1 in prostate cancer cells. J Cell Physiol 234:802-815
Burton, Liza J; Henderson, Veronica; Liburd, Latiffa et al. (2017) Snail transcription factor NLS and importin ?1 regulate the subcellular localization of Cathepsin L and Cux1. Biochem Biophys Res Commun 491:59-64
Morton, Derrick J; Patel, Divya; Joshi, Jugal et al. (2017) ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation. Oncotarget 8:2536-2549
Barrett, Cachétne S X; Millena, Ana C; Khan, Shafiq A (2017) TGF-? Effects on Prostate Cancer Cell Migration and Invasion Require FosB. Prostate 77:72-81
Joshi, Jugal Bharat; Patel, Divya; Morton, Derrick J et al. (2017) Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52. Mol Oncol 11:337-357
Yu, Min; Wang, Ulrica; Wang, Zhengxin (2016) E2F and GATA switches turn off WD repeat domain 77 expression in differentiating cells. Biochem J 473:2331-43

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