Some of the excess CVD mortality in AAs can be attributed to a higher prevalence of modifiable risk factors and their cardiovascular consequences, particulariy hypertension. There is a 62.9% prevalence of hypertension in the JHS cohort (Wyatt et. al, 2008). Hypertensive target organ-damage is also seen more frequently, is typically more severe, and occurs at younger ages in AAs. In particular, renal failure and left ventricular hypertrophy (LVH) are more common in AA than EA hypertensive individuals at comparable levels of blood pressure (Klag, 1997). Other risk factors more common in AAs than EAs include type 2 diabetes mellitus, high density lipoprotein (HDL) cholesterol, increased lipoprotein (Lp), and obesity (in women). While biologic and genetic influences on CVD risk may vary by ethnicity, they interact with and are modified by environmental variables including cultural, psychosocial, and economic issues. At least half the excess risk in AAs is unexplained (Jones et al., 2002. Relationships exist between disease states and obesity and body composition, including body mass index (BMI), total body weight, waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio, and body surface area (Ochs-Balcom, 2006). Koziel (2007) reported that lung function was related to Increased skin-fold thicknesses and subcutaneous and visceral fat deposits and that subcutaneous fat in the upper thorax affected certain organ function more than other body composition measures, including visceral and subcutaneous abdominal fat. In addition, about half of all causes of mortality in the U.S. are linked to social and behavioral factors, like diet and sedentary life-style (lOM, 2000).

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Exploratory Grants (P20)
Project #
5P20MD006899-03
Application #
8611743
Study Section
Special Emphasis Panel (ZMD1-RN)
Project Start
Project End
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
3
Fiscal Year
2014
Total Cost
$159,716
Indirect Cost
$35,521
Name
Jackson State University
Department
Type
DUNS #
044507085
City
Jackson
State
MS
Country
United States
Zip Code
39217
Mendy, Vincent L; Vargas, Rodolfo; Cannon-Smith, Gerri et al. (2018) Food Insecurity and Cardiovascular Disease Risk Factors among Mississippi Adults. Int J Environ Res Public Health 15:
Sims, Jennifer N; Yedjou, Clement G; Abugri, Daniel et al. (2018) Racial Disparities and Preventive Measures to Renal Cell Carcinoma. Int J Environ Res Public Health 15:
Horowitz, Carol R; Shameer, Khader; Gabrilove, Janice et al. (2017) Accelerators: Sparking Innovation and Transdisciplinary Team Science in Disparities Research. Int J Environ Res Public Health 14:
Mendy, Vincent L; Vargas, Rodolfo; Payton, Marinelle (2017) Trends in mortality rates by subtypes of heart disease in Mississippi, 1980-2013. BMC Cardiovasc Disord 17:158
Dehghani Firouzabadi, Ali; McDonald, Tiffany C; Samms, Tametria R et al. (2017) Disparities in HIV Clinical Outcomes among a Cohort of HIV-Infected Persons Receiving Care-Mississippi. Int J Environ Res Public Health 14:
Mendy, Vincent L; Vargas, Rodolfo; Cannon-Smith, Gerri et al. (2017) Overweight, Obesity, and Extreme Obesity Among Mississippi Adults, 2001-2010 and 2011-2015. Prev Chronic Dis 14:E49
Mendy, Vincent L; Vargas, Rodolfo; Cannon-Smith, Gerri et al. (2017) Electronic Cigarette Use among Mississippi Adults, 2015. J Addict 2017:5931736
Balakrishnan, Revathi; Kaplan, Benjamin; Negron, Rennie et al. (2017) Life after Stroke in an Urban Minority Population: A Photovoice Project. Int J Environ Res Public Health 14:
Addison, Clifton; Jenkins, Brenda W Campbell; White, Monique et al. (2017) Perception of Policy and Environmental Action to Promote Healthy Behaviors in African American Communities. Int J Environ Res Public Health 14:
Divers, Jasmin; Palmer, Nicholette D; Langefeld, Carl D et al. (2017) Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes. BMC Genet 18:105

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