Preliminary data from MH-50165 and its Supplement suggest that combination Li/Dvpx results in? ? marked antimanic effectiveness in rapid-cycling BPD, but modest antidepressant effects. Most of the non-response? ? was attributable to treatment-resistant depression (73% and 62% resistant depression and 27% and 38% resistant? ? hypomania/mania/mixed, respectively). We believe these data suggest that more broadly effective regimens are? ? needed, e.g., the addition of a third agent with more potent antidepressant properties. To address this need, R21? ? MH-62650 is supporting a modified random assignment, single-center, 6-month, double blind, balanced parallelgroup? ? comparison of two regimens of combination therapy (lithium/divalproex/blinded lamotrigine versus? ? lithium/divalproex/placebo) for the acute and continuation outpatient management of depression, hypomania, and? ? mania in 90 patients presenting in an index episode of depression. Project #3 proposes to carry out a similarly? ? designed study, but in patients who are currently comorbid with alcohol, cocaine, and/or cannabis? ? abuse dependence. To date, there are no published randomized, controlled trials in adults with BPD who are? ? currently abusing alcohol or drugs.? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Exploratory Grants (P20)
Project #
5P20MH066054-05
Application #
7551688
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2007-06-01
Project End
2008-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
5
Fiscal Year
2007
Total Cost
$14,318
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Demeter, Christine A; Youngstrom, Eric A; Carlson, Gabrielle A et al. (2013) Age differences in the phenomenology of pediatric bipolar disorder. J Affect Disord 147:295-303
Findling, Robert L; Youngstrom, Eric A; McNamara, Nora K et al. (2012) Double-blind, randomized, placebo-controlled long-term maintenance study of aripiprazole in children with bipolar disorder. J Clin Psychiatry 73:57-63
Cole, David A; Cho, Sun-Joo; Martin, Nina C et al. (2012) Are increased weight and appetite useful indicators of depression in children and adolescents? J Abnorm Psychol 121:838-51
Muzina, David J; Gao, Keming; Kemp, David E et al. (2011) Acute efficacy of divalproex sodium versus placebo in mood stabilizer-naive bipolar I or II depression: a double-blind, randomized, placebo-controlled trial. J Clin Psychiatry 72:813-9
Findling, Robert L; McNamara, Nora K; Youngstrom, Eric A et al. (2011) An open-label study of aripiprazole in children with a bipolar disorder. J Child Adolesc Psychopharmacol 21:345-51
Wang, Zuowei; Kemp, David E; Chan, Philip K et al. (2011) Comparisons of the tolerability and sensitivity of quetiapine-XR in the acute treatment of schizophrenia, bipolar mania, bipolar depression, major depressive disorder, and generalized anxiety disorder. Int J Neuropsychopharmacol 14:131-42
Cole, David A; Cai, Li; Martin, Nina C et al. (2011) Structure and measurement of depression in youths: applying item response theory to clinical data. Psychol Assess 23:819-33
Gao, Keming; Kemp, David E; Fein, Elizabeth et al. (2011) Number needed to treat to harm for discontinuation due to adverse events in the treatment of bipolar depression, major depressive disorder, and generalized anxiety disorder with atypical antipsychotics. J Clin Psychiatry 72:1063-71
Gao, Keming; Chan, Philip K; Verduin, Marcia L et al. (2010) Independent predictors for lifetime and recent substance use disorders in patients with rapid-cycling bipolar disorder: focus on anxiety disorders. Am J Addict 19:440-9
Gao, Keming; Kemp, David E; Wang, Zuowei et al. (2010) Predictors of non-stabilization during the combination therapy of lithium and divalproex in rapid cycling bipolar disorder: a post-hoc analysis of two studies. Psychopharmacol Bull 43:23-38

Showing the most recent 10 out of 40 publications